• 1. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 2. Fast-Track to Research Data Management in Experimental Material Science-Setting the Ground for Research Group Level Materials Digitalization.
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• 3. Distinction of trans–cis photoisomers with comparable optical properties in multiple-state photochromic systems – examining a molecule with three azobenzenes via in situ irradiation NMR spectroscopy?
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• 5. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
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• Solvents and Organic Chemicals Organic Compounds Amines/Sulfonamides
• Solvents and Organic Chemicals Organic Compounds

Professional Introduction to 2-Naphthylamine-6-sulfomethylamide (CAS No. 104295-55-8)

2-Naphthylamine-6-sulfomethylamide, a compound with the chemical identifier CAS No. 104295-55-8, represents a significant molecule in the realm of pharmaceutical and biochemical research. This compound, characterized by its naphthylamine core structure and sulfomethylamide functional group, has garnered attention due to its versatile applications in medicinal chemistry and drug development. The unique structural attributes of this molecule make it a valuable candidate for further exploration in various therapeutic areas.

The molecular framework of 2-Naphthylamine-6-sulfomethylamide consists of a naphthalene ring system substituted with an amine group at the 2-position and a sulfomethylamide moiety at the 6-position. This configuration imparts distinct chemical properties that are exploited in synthetic chemistry and biological assays. The sulfomethylamide group, in particular, contributes to the compound's solubility and reactivity, making it an attractive scaffold for designing novel bioactive molecules.

In recent years, there has been a surge in research focused on developing new therapeutic agents derived from heterocyclic compounds. Among these, derivatives of naphthylamine have shown promise in treating a variety of diseases, including cancer, infectious disorders, and inflammatory conditions. The introduction of the sulfomethylamide group into the naphthylamine core enhances the compound's pharmacological profile, potentially improving its binding affinity to biological targets and metabolic stability.

One of the most compelling aspects of 2-Naphthylamine-6-sulfomethylamide is its potential as a precursor in the synthesis of more complex pharmaceutical entities. Researchers have leveraged its structural features to develop novel inhibitors targeting enzymes involved in disease pathways. For instance, studies have demonstrated its utility in creating compounds that modulate kinases and other signaling proteins, which are critical in cancer progression. The sulfomethylamide moiety serves as a handle for further functionalization, allowing chemists to tailor the molecule's properties for specific biological activities.

The sulfomethylamide group also plays a crucial role in enhancing the compound's solubility in aqueous environments, which is a desirable trait for drug formulations intended for oral or injectable administration. This property is particularly important in drug development, where bioavailability and distribution within the body are key factors determining therapeutic efficacy. Additionally, the presence of charged or polar functional groups like sulfomethylamides can improve binding interactions with protein targets, leading to higher affinity and prolonged duration of action.

Recent advancements in computational chemistry have further accelerated the exploration of 2-Naphthylamine-6-sulfomethylamide and its derivatives. Molecular modeling techniques allow researchers to predict the binding modes of this compound with various biological targets with remarkable accuracy. These predictions are invaluable in guiding experimental efforts and optimizing lead structures for drug development. By integrating computational methods with traditional synthetic approaches, scientists can efficiently screen large libraries of compounds for potential therapeutic applications.

The pharmaceutical industry has shown particular interest in developing small-molecule inhibitors based on naphthylamine derivatives due to their reported efficacy and safety profiles. The structural versatility of 2-Naphthylamine-6-sulfomethylamide makes it an ideal candidate for generating analogs with enhanced pharmacological properties. Researchers have employed strategies such as structure-based drug design and high-throughput screening to identify promising candidates for further development.

In conclusion, 2-Naphthylamine-6-sulfomethylamide (CAS No. 104295-55-8) represents a fascinating molecule with significant potential in pharmaceutical research. Its unique structural features and functional groups make it a valuable scaffold for developing novel therapeutic agents targeting various diseases. As research continues to uncover new applications for this compound, it is likely to play an increasingly important role in drug discovery and development efforts worldwide.

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• 61209-69-6(1-Naphthalenesulfonamide, N-phenyl-)
• 1709-52-0(4-amino-N-methylbenzene-1-sulfonamide)
• 1576-48-3(2-Naphthalenesulfonamide,N-phenyl-)
• 15309-82-7(Benzenesulfonamide, N-1-naphthalenyl-)
• 1214-03-5(1-Naphthalenesulfonamide,6-amino-N,N-dimethyl-)
• 55691-85-5(Benzenesulfonamide, N-(4-amino-1-naphthalenyl)-)