• 1. Distinct correlation between (CN2)x units and pores: a low-cost method for predesigned wide range control of micropore size of porous carbon?
  Xiaotong Feng,Lei Bian,Jie Ma,Lei Zhou,Xiayan Wang,Guangsheng Guo,Qiaosheng Pu Chem. Commun., 2019,55, 3963-3966
• 2. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 3. Emerging investigator series: first-principles and thermodynamics comparison of compositionally-tuned delafossites: cation release from the (001) surface of complex metal oxides?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives

Comprehensive Overview of 3-(Trifluoromethyl)pyridine-2-sulfonyl Chloride (CAS No. 104040-75-7)

3-(Trifluoromethyl)pyridine-2-sulfonyl Chloride (CAS No. 104040-75-7) is a highly versatile sulfonyl chloride derivative widely utilized in pharmaceutical and agrochemical research. Its unique trifluoromethyl group and reactive sulfonyl chloride moiety make it a critical intermediate for synthesizing bioactive compounds. Researchers frequently search for "3-(Trifluoromethyl)pyridine-2-sulfonyl Chloride synthesis" or "CAS 104040-75-7 applications," reflecting its significance in modern organic chemistry.

The compound's molecular structure combines a pyridine ring with a sulfonyl chloride functional group, enabling diverse reactivity. This feature aligns with trending topics like "fluorinated building blocks in drug discovery" and "high-value chemical intermediates." Its stability under controlled conditions and compatibility with cross-coupling reactions further enhance its utility, addressing common queries such as "how to handle sulfonyl chlorides safely" and "trifluoromethylpyridine derivatives in medicinal chemistry."

In pharmaceutical applications, 3-(Trifluoromethyl)pyridine-2-sulfonyl Chloride serves as a precursor for enzyme inhibitors and kinase modulators. Recent studies highlight its role in developing anticancer agents and antiviral drugs, resonating with popular searches like "fluorinated compounds in COVID-19 research." The agrochemical industry also leverages its properties to create herbicides and pesticides with improved efficacy, a topic often explored under "sustainable crop protection chemicals."

From a synthetic perspective, the compound's electrophilic character facilitates nucleophilic substitutions, making it ideal for constructing sulfonamides and sulfonate esters. Laboratories frequently inquire about "optimizing yields for 3-(Trifluoromethyl)pyridine-2-sulfonyl Chloride reactions" or "alternative solvents for sulfonylation," underscoring its technical relevance. Innovations in green chemistry have further driven interest in eco-friendly protocols for its use.

Analytical methods for characterizing CAS 104040-75-7 include NMR spectroscopy, HPLC purity analysis, and mass spectrometry. These techniques address quality control concerns, a recurring theme in queries like "how to validate sulfonyl chloride purity." Storage recommendations typically emphasize anhydrous environments to prevent hydrolysis, a practical consideration for industrial users.

Emerging trends in precision medicine and bioconjugation have expanded the demand for specialized intermediates like 3-(Trifluoromethyl)pyridine-2-sulfonyl Chloride. Its compatibility with click chemistry and proteolysis-targeting chimeras (PROTACs) aligns with cutting-edge research areas. This synergy positions the compound as a focal point for discussions on "next-generation drug design tools" and "fluorine in bioactive molecules."

In summary, 3-(Trifluoromethyl)pyridine-2-sulfonyl Chloride (CAS No. 104040-75-7) bridges fundamental research and industrial applications through its multifaceted reactivity. By addressing both academic curiosity ("mechanistic studies of sulfonyl chlorides") and practical needs ("scaling up pyridine derivatives"), it remains a cornerstone in synthetic and applied chemistry.

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