Cas no 1040250-19-8 (Olmesartan dimer ester impurity)

Olmesartan dimer ester impurity is a critical reference standard used in pharmaceutical analysis, particularly for the quality control of Olmesartan medoxomil and related compounds. This impurity is structurally characterized as a dimeric ester derivative of Olmesartan, formed during synthesis or storage. Its primary utility lies in method development, validation, and impurity profiling to ensure compliance with regulatory standards (e.g., ICH guidelines). High-purity grades of this impurity enable accurate quantification and identification in HPLC or LC-MS analyses, supporting robust analytical workflows. Its well-defined chemical properties and stability make it indispensable for assessing batch consistency and drug safety in angiotensin II receptor antagonist formulations.
Olmesartan dimer ester impurity structure
1040250-19-8 structure
Product Name:Olmesartan dimer ester impurity
CAS No:1040250-19-8
MF:C48H50N12O5
MW:874.988
CID:830900
PubChem ID:71476577
Update Time:2025-06-07

Olmesartan dimer ester impurity Chemical and Physical Properties

Names and Identifiers

    • 5-amino-6-chloropicolinaldehyde
    • 5-[2-[5-(2-hydroxypropan-2-yl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carbonyl]oxypropan-2-yl]-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carbox
    • Olmesartan Dimer
    • Olmesartan Dimer Est
    • OlMesartan DiMer Ester IMpurity
    • Olmesartan medoxomil impurity IV
    • Olmesartan Dimer Ester ImpuritynnDiscontinued
    • 4-(1-Hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylic acid 1-[5-carboxy-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazol-4-yl]-1-methylethyl ester
    • OlMesartan DiMer Ester
    • Olmesartan medoxomil impurity Ⅳ
    • Olmesartan Dimer Ester(RNH-8276)
    • Olmesartan MedoxomiI Dimer Ether Impurity
    • OlMesartan DiMer Ester IMpurity Discontinued
    • 4-(1-Hydroxy-1-Methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]Methyl]-1H-iMidazole-5-carboxylic Acid
    • 1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-((1-((2'-(2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypropan-2-yl)-2-propyl-1H-imidazole-5-carbonyl)oxy)propan-2-yl)-2-propyl-1H-imidazole-5-carboxylic acid
    • 4-{2-[4-(2-hydroxypropan-2-yl)-2-propyl-1-{[2'-(2H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carbonyloxy]propan-2-yl}-2-propyl-1-{[2'-(2H-1,2,3,4-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylic acid
    • 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-, 1-(5-carboxy-2-propyl-1-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazol-4-yl)-1-methylethyl ester
    • BCP27850
    • 4-(2-{[4-(2-Hydroxypropan-2-yl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carbonyl]oxy}propan-2-yl)-2-propyl-1-{[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl}-1H-imidazole-5-carboxylic acid
    • 1040250-19-8
    • UNII-SCW5UZ5MAZ
    • J-502807
    • SCW5UZ5MAZ
    • 1-[5-Carboxy-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazol-4-yl]-1-methylethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-carboxylate
    • 1H-Imidazole-5-carboxylic acid, 4-(1-hydroxy-1-methylethyl)-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-, 1-[5-carboxy-2-propyl-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazol-4-yl]-1-methylethyl ester
    • 1-(5-Carboxy-2-propyl-1-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazol-4-yl)-1-methylethyl 4-(1-hydroxy-1-methylethyl)-2-propyl-1-((2'-(2H-tetrazol-5-yl)(1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-carboxylate
    • 4-(2-(4-(2-Hydroxypropan-2-yl)-2-propyl-1-((2'-(2H-1,2,3,4-tetrazol-5-yl)-(1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-carbonyloxy)propan-2-yl)-2-propyl-1-((2'-(2H-1,2,3,4-tetrazol-5-yl)-(1,1'-biphenyl)-4-yl)methyl)-1H-imidazole-5-carboxylic acid
    • 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-((1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-4-(2-hydroxypro pan-2-yl)-2-propyl-1H-imidazole-5-carbonyl)oxy)propan-2-yl)-2-propyl
    • DTXSID50856130
    • Olmesartan dimer ester impurity
    • Inchi： InChI=1S/C48H50N12O5/c1-7-13-37-49-41(47(3,4)64)40(60(37)28-30-21-25-32(26-22-30)34-16-10-12-18-36(34)44-53-57-58-54-44)46(63)65-48(5,6)42-39(45(61)62)59(38(50-42)14-8-2)27-29-19-23-31(24-20-29)33-15-9-11-17-35(33)43-51-55-56-52-43/h9-12,15-26,64H,7-8,13-14,27-28H2,1-6H3,(H,61,62)(H,51,52,55,56)(H,53,54,57,58)
    • InChI Key： QTZDCAYLDWDQKW-UHFFFAOYSA-N
    • SMILES： CCCC1=NC(=C(N1CC2=CC=C(C=C2)C3=CC=CC=C3C4=NNN=N4)C(=O)O)C(C)(C)OC(=O)C5=C(N=C(N5CC6=CC=C(C=C6)C7=CC=CC=C7C8=NNN=N8)CCC)C(C)(C)O

Computed Properties

  • Exact Mass: 874.40300
  • Monoisotopic Mass: 874.40271274g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 4
  • Hydrogen Bond Acceptor Count: 13
  • Heavy Atom Count: 65
  • Rotatable Bond Count: 18
  • Complexity: 1550
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 7.3
  • Topological Polar Surface Area: 228?2

Experimental Properties

  • Density: 1.35±0.1 g/cm3 (20 oC 760 Torr),
  • Solubility: Insuluble (1.3E-4 g/L) (25 oC),
  • PSA: 228.39000
  • LogP: 7.79310

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