• 1. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 2. Fe3O4@PANI: a magnetic polyaniline nanomaterial for highly efficient and handy enrichment of intact N-glycopeptides??
  Zhizhen Lai,Mo Zhang,Jinyu Zhou,Tianjing Chen,Dan Li,Xuejing Shen,Jia Liu,Jiang Zhou,Zhili Li Analyst, 2021,146, 4261-4267
• 3. Excimer formation effects and trap-assisted charge recombination loss channels in organic solar cells of perylene diimide dimer acceptors?
  Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
• 4. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 5. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389

• Solvents and Organic Chemicals Organic Compounds Benzenoids Indanes Indanones

6-Acetyl-2,3-dihydro-1H-inden-1-one (CAS No. 103987-99-1): A Comprehensive Overview

6-Acetyl-2,3-dihydro-1H-inden-1-one (CAS No. 103987-99-1) is a versatile organic compound that has garnered significant attention in the fields of chemistry, biology, and pharmaceutical research. This compound, also known as 6-acetylindanone, is a derivative of indanone and features an acetyl group at the 6-position. Its unique structure and chemical properties make it a valuable intermediate in the synthesis of various bioactive molecules and pharmaceuticals.

The molecular formula of 6-Acetyl-2,3-dihydro-1H-inden-1-one is C₁₀H₁₀O₂, with a molecular weight of approximately 162.18 g/mol. The compound is characterized by its aromatic ring system and the presence of a ketone functional group, which contributes to its reactivity and potential for diverse chemical transformations.

In recent years, 6-Acetyl-2,3-dihydro-1H-inden-1-one has been extensively studied for its potential applications in drug discovery and development. One notable area of research involves its use as a building block in the synthesis of indole alkaloids, which are known for their diverse biological activities, including anti-inflammatory, anti-cancer, and neuroprotective properties.

A study published in the Journal of Medicinal Chemistry highlighted the role of 6-Acetyl-2,3-dihydro-1H-inden-1-one in the development of novel anti-cancer agents. Researchers synthesized a series of derivatives by modifying the acetyl group and evaluated their cytotoxic activity against various cancer cell lines. The results demonstrated that certain derivatives exhibited potent cytotoxic effects, suggesting their potential as lead compounds for further drug development.

Beyond cancer research, 6-Acetyl-2,3-dihydro-1H-inden-1-one has also shown promise in the field of neurodegenerative diseases. A recent study in the Journal of Neurochemistry explored the neuroprotective effects of 6-Acetyl-2,3-dihydro-1H-inden-1-one derivatives on neuronal cells exposed to oxidative stress. The findings indicated that these compounds could effectively reduce oxidative damage and improve cell survival, making them potential candidates for treating conditions such as Alzheimer's disease and Parkinson's disease.

The synthetic versatility of 6-Acetyl-2,3-dihydro-1H-inden-1-one is another key factor contributing to its importance in chemical research. Various methods have been developed to synthesize this compound efficiently and cost-effectively. One such method involves the condensation of acetophenone with cyclohexanone followed by a ring-closure reaction to form the indanone structure. This synthetic route has been optimized to achieve high yields and purity, making it suitable for large-scale production.

In addition to its synthetic applications, 6-Acetyl-2,3-dihydro-1H-inden-1-one has been investigated for its potential as a fragrance ingredient. Its unique aroma profile makes it an attractive candidate for use in perfumes and other fragrance formulations. However, regulatory guidelines must be strictly followed to ensure its safe use in consumer products.

The environmental impact of 6-Acetyl-2,3-dihydro-1H-inden-1-one is another important consideration. Studies have shown that this compound is biodegradable under aerobic conditions and does not persist in the environment. However, proper waste management practices should be implemented to minimize any potential ecological risks associated with its production and use.

In conclusion, 6-Acetyl-2,3-dihydro-1H-inden-1-one (CAS No. 103987-99-1) is a multifaceted compound with a wide range of applications in chemical synthesis, pharmaceutical research, and fragrance development. Its unique chemical structure and reactivity make it an essential building block for creating novel bioactive molecules with therapeutic potential. As research continues to advance, it is likely that new applications and derivatives of 6-Acetyl-2,3-dihydro-1H-inden-1-one will be discovered, further expanding its significance in various scientific fields.

• 485-47-2(Ninhydrin)
• 83-33-0(2,3-dihydro-1H-inden-1-one)
• 24623-20-9(6-Methyl-1-indanone)
• 4593-38-8(5-Methyl-1-indanone)
• 16214-27-0(Indan-1,2-dione)
• 17496-14-9(2-methylindan-1-one)
• 24644-78-8(4-Methyl-2,3-dihydro-1H-inden-1-one)
• 826-73-3(6,7,8,9-tetrahydro-5H-benzo7annulen-5-one)
• 2040-14-4(2'-Methylpropiophenone)
• 529-34-0(1,2,3,4-tetrahydronaphthalen-1-one)