• 1. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 3. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 4. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 5. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Diphenylethers

Introduction to [2-(3,4-Dimethylphenoxy)phenyl]methanol (CAS No. 1039866-07-3)

[2-(3,4-Dimethylphenoxy)phenyl]methanol is a significant compound in the field of pharmaceutical chemistry, characterized by its unique structural and functional properties. This compound, identified by the CAS number 1039866-07-3, has garnered considerable attention due to its potential applications in drug development and synthetic chemistry. The presence of two aromatic rings linked by a methanol side chain, along with the dimethyl substitution on the phenoxy ring, contributes to its distinct chemical behavior and reactivity.

The molecular structure of [2-(3,4-Dimethylphenoxy)phenyl]methanol consists of a benzene ring substituted with a phenoxy group at the 2-position and dimethyl groups at the 3- and 4-positions. This configuration imparts specific electronic and steric properties that make it a valuable intermediate in organic synthesis. The compound's solubility profile and interaction with biological systems have been subjects of extensive research, particularly in the context of developing novel therapeutic agents.

In recent years, [2-(3,4-Dimethylphenoxy)phenyl]methanol has been explored for its role in synthesizing bioactive molecules. Its aromatic framework provides a versatile scaffold for further functionalization, enabling the creation of derivatives with enhanced pharmacological properties. Researchers have leveraged this compound to develop new ligands for enzyme inhibition and receptor binding studies. The dimethylphenoxy moiety, in particular, has been found to influence binding affinity and metabolic stability, making it a crucial element in medicinal chemistry.

One of the most compelling aspects of [2-(3,4-Dimethylphenoxy)phenyl]methanol is its potential in addressing unmet medical needs. Studies have demonstrated its utility in designing compounds that target neurological disorders, cardiovascular diseases, and inflammatory conditions. The compound's ability to modulate key biological pathways has opened new avenues for therapeutic intervention. For instance, its derivatives have shown promise in preclinical trials as potential treatments for neurodegenerative diseases by interacting with specific protein targets.

The synthesis of [2-(3,4-Dimethylphenoxy)phenyl]methanol involves multi-step organic reactions that highlight the compound's synthetic versatility. Advanced synthetic methodologies have been employed to optimize yield and purity, ensuring that researchers can access high-quality starting materials for their investigations. Techniques such as palladium-catalyzed cross-coupling reactions and nucleophilic aromatic substitutions have been particularly effective in constructing the desired molecular architecture.

Recent advancements in computational chemistry have further enhanced the understanding of [2-(3,4-Dimethylphenoxy)phenyl]methanol's properties. Molecular modeling studies have provided insights into its interactions with biological targets at an atomic level. These simulations have been instrumental in predicting binding affinities and optimizing drug-like characteristics. By integrating experimental data with computational predictions, researchers can design more effective molecules with improved pharmacokinetic profiles.

The pharmaceutical industry has taken notice of [2-(3,4-Dimethylphenoxy)phenyl]methanol's potential as a building block for novel drugs. Several companies are investing in research programs aimed at developing derivatives with enhanced therapeutic efficacy and reduced side effects. The compound's unique structural features make it an attractive candidate for further exploration in drug discovery pipelines. Collaborative efforts between academic institutions and pharmaceutical firms are accelerating the translation of laboratory findings into clinical applications.

In conclusion, [2-(3,4-Dimethylphenoxy)phenyl]methanol (CAS No. 1039866-07-3) represents a promising compound in pharmaceutical chemistry. Its structural features and functional properties make it a valuable intermediate for synthesizing bioactive molecules with potential therapeutic applications. Ongoing research continues to uncover new possibilities for this compound, reinforcing its importance in the development of next-generation pharmaceuticals.

• 90047-52-2(1,2-Benzenedimethanol, 3-methoxy-)
• 40870-63-1(1,2-Benzenedimethanol,3,6-dimethoxy-4,5-dimethyl-)
• 5600-82-8(Benzenemethanol, 2,5-dimethoxy-3-methyl-)
• 13807-84-6((2-Phenoxyphenyl)methanol)
• 33524-31-1(2,5-Dimethoxybenzyl Alcohol)
• 67698-67-3(Benzenemethanol, 2-(2-methylphenoxy)-)
• 10038-40-1(2,2'-Bis(hydroxymethyl)diphenyl Ether)
• 89244-39-3((2-Methoxy-6-methylphenyl)methanol)
• 51829-43-7(1,4-Benzenedimethanol, 2,5-dimethoxy-)
• 78840-04-7(2,6-Bis(hydroxymethyl)-1,4-dimethoxybenzene)