• 1. Index of subjects
  J. Chem. Soc. Abstr. 1899 76 B919
• 2. Index of subjects, 1899
  J. Chem. Soc. Trans. 1899 75 1188

Comprehensive Overview of 4-Phenylpyridine-3-carboxylic Acid (CAS No. 103863-14-5): Properties, Applications, and Research Insights

4-Phenylpyridine-3-carboxylic acid (CAS No. 103863-14-5) is a heterocyclic organic compound featuring a pyridine ring substituted with a phenyl group at the 4-position and a carboxylic acid moiety at the 3-position. This unique structure endows it with versatile chemical properties, making it a valuable intermediate in pharmaceutical synthesis, material science, and agrochemical research. The compound’s molecular formula (C₁₂H₉NO₂) and molecular weight (199.21 g/mol) are critical for stoichiometric calculations in synthetic workflows.

In recent years, 4-phenylpyridine-3-carboxylic acid derivatives have garnered attention due to their potential in drug discovery, particularly as building blocks for kinase inhibitors and antimicrobial agents. Researchers are exploring its role in medicinal chemistry, where its pharmacophore structure aligns with targets like inflammation and neurodegenerative diseases. A surge in Google Scholar citations reflects growing interest in its structure-activity relationship (SAR) studies, a trending topic in AI-driven drug design platforms.

The compound’s solubility in polar solvents (e.g., DMSO, methanol) and melting point (reported ~200–210°C) are pivotal for laboratory handling. Analytical techniques such as HPLC, NMR, and mass spectrometry are routinely employed for purity verification, addressing a common query among synthetic chemists about quality control protocols. Notably, its UV-Vis absorption profile makes it relevant in photocatalysis research, a hot topic in sustainable chemistry.

From an industrial perspective, 4-phenylpyridine-3-carboxylic acid serves as a precursor for ligand synthesis in transition-metal catalysis, a field gaining traction due to the demand for greener chemical processes. Its chelating ability is exploited in designing metal-organic frameworks (MOFs), aligning with the nanomaterials boom. SEO trends reveal high search volumes for “MOF precursors” and “heterocyclic carboxylic acids”, underscoring its commercial relevance.

Environmental and safety profiles of CAS 103863-14-5 are frequently queried in REACH compliance discussions. While not classified as hazardous, proper PPE (gloves, goggles) is recommended during handling, reflecting industry focus on lab safety standards. Its biodegradability data remains limited, a gap highlighted in recent green chemistry forums.

In academia, the compound’s crystallographic data (e.g., Cambridge Structural Database entries) supports computational modeling studies. This intersects with the rise of AI-powered molecular docking tools, a frequent search term among computational chemists. Patent analyses reveal applications in OLED materials, tying into the flexible electronics market surge.

Future research directions may explore 4-phenylpyridine-3-carboxylic acid’s role in bioorthogonal chemistry or proteolysis-targeting chimeras (PROTACs), addressing trending PubMed queries. Its scalable synthesis routes—often searched in process chemistry circles—remain an area for optimization, particularly for continuous flow systems.

In summary, 103863-14-5 exemplifies how niche heterocycles bridge multidisciplinary research. Its dual utility in life sciences and advanced materials ensures sustained interest, mirrored by SEO metrics on “specialty chemicals” and “high-value intermediates”. As open-access databases expand, collaborative studies on this compound are poised to accelerate.

• 885954-13-2(4-(Pyridin-3-yl)-1H-pyrrole-3-carboxylic acid)
• 103863-13-4(4-Phenylnicotinic acid hydrochloride)
• 1261910-85-3(4-(3,5-Dicarboxyphenyl)nicotinic acid)
• 132040-12-1(4-Phenyl-1H-pyrrole-3-carboxylic acid)
• 1261899-93-7(4-(2-Formylphenyl)nicotinic acid)
• 191668-22-1(1H-Pyrrole-3-carboxylicacid, 4-(4-methylphenyl)-)
• 1261910-17-1(4-(4-Carboxyphenyl)nicotinic acid)
• 115486-03-8([3,4'-Bipyridine]-3',5'-dicarboxylic acid)
• 1261908-60-4(4-(Naphthalen-1-yl)nicotinic acid)
• 197774-71-3(4-(Pyridin-4-yl)-1H-pyrrole-3-carboxylic acid)