Cas no 10351-88-9 (Phyllanthin)

Phyllanthin is a bioactive lignan compound primarily isolated from Phyllanthus amarus, a medicinal plant traditionally used in herbal remedies. It exhibits notable hepatoprotective properties, making it valuable in research focused on liver health and detoxification pathways. Phyllanthin has demonstrated potential as an antioxidant and anti-inflammatory agent, with studies suggesting its role in modulating lipid metabolism and mitigating oxidative stress. Its molecular structure allows for selective interaction with biological targets, enhancing its utility in pharmacological studies. The compound is typically characterized by HPLC or LC-MS for purity assessment, ensuring consistency in research applications. Its stability and well-documented mechanisms contribute to its relevance in preclinical investigations.
Phyllanthin structure
Phyllanthin structure
Product Name:Phyllanthin
CAS No:10351-88-9
MF:C24H34O6
MW:418.523168087006
MDL:MFCD17166965
CID:196196
PubChem ID:329750834
Update Time:2025-05-28

Phyllanthin Chemical and Physical Properties

Names and Identifiers

    • Benzene,1,1'-[(2S,3S)-2,3-bis(methoxymethyl)-1,4-butanediyl]bis[3,4-dimethoxy-
    • PHYLLANTHIN
    • (2S,3S)-(+)-1,4-Dimethoxy-2,3-diveratrylbutane
    • PHYLLANTHIN(P)
    • PHYLLANTHIN(P) PrintBack
    • phyllantin
    • NSC 619043
    • [ "" ]
    • NSC619043
    • 75O1TFF47Z
    • NCI60_005684
    • C24H34O6
    • Phyllanthin, analytical standard
    • 4-[(2S,3S)-3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-1,2-dimethoxybenzene
    • Benzene, 1,1'-(2,3-bis(methoxymethyl)-1,4-butanediyl)bis(3,4-dimethoxy-, (S-(R*,R*))-
    • W1810
    • C10746
    • Phyllanthin, United States Pharmacopeia (USP) Reference Standard
    • Benzene,1,1'-[(2S,3S)-2,3-bis(meth
    • PHYLLANTHIN (CONSTITUENT OF PHYLLANTHUS AMARUS) [DSC]
    • BENZENE, 1,1'-((2S,3S)-2,3-BIS(METHOXYMETHYL)-1,4-BUTANEDIYL)BIS(3,4-DIMETHOXY-
    • HY-N4107
    • MS-27324
    • PHYLLANTHIN [USP-RS]
    • CHEBI:8177
    • DTXSID001319088
    • CS-0032115
    • UNII-75O1TFF47Z
    • NSC-619043
    • A1-06840
    • AC1L7DK7
    • 3,3',4,4',9,9'-Hexamethoxylignan
    • PHYLLANTHIN (CONSTITUENT OF PHYLLANTHUS AMARUS)
    • Tetra-O-methylsecoisolariciresinol
    • AKOS032948449
    • 4-[(2S,3S)-3-[(3,4-dimethoxyphenyl)methyl]-4-methoxy-2-(methoxymethyl)butyl]-1,2-dimethoxy-benzene
    • PHYLLANTHIN (USP-RS)
    • CHEMBL1253999
    • 10351-88-9
    • Q27107847
    • BUTANE, 1,4-DIMETHOXY-2,3-DIVERATRYL-, (2S,3S)-(+)-
    • 3,3',4,4',9,9'-Hexahydroxylignan; (8S,8'S)-form, Hexa-Me ether
    • KFLQGJQSLUYUBF-WOJBJXKFSA-N
    • DA-56827
    • Phyllanthin
    • MDL: MFCD17166965
    • Inchi: 1S/C24H34O6/c1-25-15-19(11-17-7-9-21(27-3)23(13-17)29-5)20(16-26-2)12-18-8-10-22(28-4)24(14-18)30-6/h7-10,13-14,19-20H,11-12,15-16H2,1-6H3/t19-,20-/m1/s1
    • InChI Key: KFLQGJQSLUYUBF-WOJBJXKFSA-N
    • SMILES: O(C)C[C@@H](CC1C=CC(=C(C=1)OC)OC)[C@@H](COC)CC1C=CC(=C(C=1)OC)OC

Computed Properties

  • Exact Mass: 418.23600
  • Monoisotopic Mass: 418.236
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 0
  • Hydrogen Bond Acceptor Count: 6
  • Heavy Atom Count: 30
  • Rotatable Bond Count: 13
  • Complexity: 407
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 2
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 55.4
  • Molecular Weight: 418.5
  • XLogP3: 4.2

Experimental Properties

  • Color/Form: Powder
  • Density: 1.069
  • Melting Point: 96 oC
  • Boiling Point: 530.6°Cat760mmHg
  • Flash Point: 207.3°C
  • Refractive Index: 1.516
  • PSA: 55.38000
  • LogP: 4.03140
  • Vapor Pressure: 0.0±1.3 mmHg at 25°C

Phyllanthin Security Information

Phyllanthin Customs Data

  • HS CODE:2909309090
  • Customs Data:

    China Customs Code:

    2909309090

    Overview:

    2909309090 Other aromatic ethers and their halogenated derivatives\sulfonation\Nitrated derivative(Including nitrosative derivatives).Regulatory conditions:nothing.VAT:17.0%.Tax refund rate:9.0%.MFN tariff:5.5%.general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2909309090 other aromatic ethers and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Phyllanthin Pricemore >>

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Additional information on Phyllanthin

Comprehensive Analysis of Phyllanthin (CAS No. 10351-88-9): Properties, Applications, and Research Insights

Phyllanthin (CAS No. 10351-88-9) is a bioactive lignan compound predominantly extracted from the plant Phyllanthus amarus, a herb widely used in traditional medicine. With increasing interest in natural therapeutics, Phyllanthin has garnered attention for its potential hepatoprotective, anti-inflammatory, and antioxidant properties. Researchers and healthcare professionals are exploring its mechanisms of action, particularly in liver health and metabolic disorders, aligning with the growing demand for plant-derived supplements.

The molecular structure of Phyllanthin (C24H30O7) features a dibenzylbutyrolactone skeleton, which contributes to its unique pharmacological profile. Studies highlight its ability to modulate enzymes like cytochrome P450, making it a subject of interest in drug metabolism research. As consumers increasingly search for "natural liver support compounds" or "Phyllanthin benefits for fatty liver," this compound’s relevance in nutraceutical formulations continues to rise.

In recent years, Phyllanthin has been investigated for its role in managing oxidative stress and inflammation, two key factors linked to chronic diseases. Its potential synergy with other phytochemicals, such as hypophyllanthin, enhances its therapeutic value. Online queries like "Phyllanthin vs. silymarin for liver health" reflect comparative interest among users seeking evidence-based alternatives to conventional supplements.

From an industrial perspective, Phyllanthin extraction and purification methods are critical to ensuring product efficacy. Advanced techniques like HPLC and mass spectrometry are employed to standardize its concentration in herbal extracts, addressing concerns about "Phyllanthin supplement quality control." Regulatory bodies emphasize the need for standardized extracts to meet safety and potency benchmarks, a topic frequently discussed in phytopharmaceutical forums.

Emerging trends also link Phyllanthin to metabolic syndrome research, particularly in glucose and lipid metabolism. Preclinical studies suggest its ability to improve insulin sensitivity, resonating with searches like "natural compounds for diabetes management." However, further clinical trials are needed to validate these findings, a gap often highlighted in scientific literature.

Environmental and sustainability factors further influence the Phyllanthin market. Ethical sourcing of Phyllanthus amarus and eco-friendly extraction methods are becoming priorities, as seen in searches for "sustainable Phyllanthin production." This aligns with the broader shift toward green chemistry in the nutraceutical industry.

In conclusion, Phyllanthin (CAS No. 10351-88-9) represents a promising intersection of traditional medicine and modern science. Its multifaceted applications—from liver health to metabolic support—coupled with rigorous quality standards, position it as a key player in the evolving landscape of natural therapeutics. As research progresses, addressing user queries like "how to identify pure Phyllanthin" or "Phyllanthin dosage guidelines" will be essential for bridging knowledge gaps and fostering informed consumer choices.

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