• 1. Estimating and correcting interference fringes in infrared spectra in infrared hyperspectral imaging
  Ghazal Azarfar,Ebrahim Aboualizadeh,Nicholas M. Walter,Simona Ratti,Camilla Olivieri,Alessandra Norici,Michael Nasse,Achim Kohler,Mario Giordano Analyst, 2018,143, 4674-4683
• 2. Excited state potential energy surfaces and their interactions in FeIVO active sites
  Shaun D. Wong,Edward I. Solomon Dalton Trans., 2014,43, 17567-17577
• 3. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Exceptionally high temperature spin crossover in amide-functionalised 2,6-bis(pyrazol-1-yl)pyridine iron(ii) complex revealed by variable temperature Raman spectroscopy and single crystal X-ray diffraction?
  Max Attwood,Hiroki Akutsu,Lee Martin,Toby J. Blundell,Pierre Le Maguere,Scott S. Turner Dalton Trans., 2021,50, 11843-11851
• 5. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339

Benzyl 1-methyl-1H-indole-3-carboxylate (CAS No. 1033693-00-3): A Comprehensive Overview

Benzyl 1-methyl-1H-indole-3-carboxylate, identified by the Chemical Abstracts Service registry number CAS No. 1033693-00-3, is a significant compound in the realm of pharmaceutical chemistry and medicinal research. This compound, characterized by its benzyl ester and indole core structure, has garnered attention due to its potential applications in drug development and synthetic chemistry. The indole moiety, a prominent feature in numerous bioactive molecules, contributes to the compound's pharmacological relevance, making it a subject of extensive interest among researchers.

The structural framework of Benzyl 1-methyl-1H-indole-3-carboxylate consists of a benzyl group attached to the carboxylate functionality of a methylated indole ring. This configuration not only imparts unique chemical properties but also opens up diverse synthetic pathways for further derivatization. The presence of the methyl group at the 1-position of the indole ring enhances its metabolic stability and influences its interaction with biological targets, making it a valuable scaffold for designing novel therapeutic agents.

In recent years, there has been a surge in research focusing on indole derivatives due to their broad spectrum of biological activities. Benzyl 1-methyl-1H-indole-3-carboxylate has been explored for its potential role in various pharmacological contexts. Studies have highlighted its significance in modulating enzyme activity and interacting with specific protein receptors. For instance, research indicates that derivatives of this compound may exhibit inhibitory effects on certain enzymes involved in inflammatory pathways, suggesting its therapeutic potential in managing chronic inflammatory conditions.

Moreover, the benzyl ester group in Benzyl 1-methyl-1H-indole-3-carboxylate provides a versatile handle for further chemical modifications. This feature allows researchers to explore diverse functionalization strategies, enabling the synthesis of structurally diverse analogs with tailored pharmacological properties. The ability to modify both the indole core and the benzyl ester segment offers a rich ground for developing new drug candidates targeting various diseases.

Recent advancements in computational chemistry and molecular modeling have further accelerated the exploration of Benzyl 1-methyl-1H-indole-3-carboxylate. These techniques have enabled researchers to predict binding affinities and interactions with biological targets with high precision. Such insights are crucial for rational drug design, allowing for the optimization of lead compounds before they enter preclinical testing. The integration of computational methods with experimental validation has streamlined the drug discovery process, making compounds like Benzyl 1-methyl-1H-indole-3-carboxylate more accessible for therapeutic development.

The pharmaceutical industry has shown particular interest in indole derivatives due to their well-documented biological activities. Benzyl 1-methyl-1H-indole-3-carboxylate is no exception, with preliminary studies suggesting its potential utility in addressing neurological disorders. The indole scaffold is known to interact with neurotransmitter systems, making it a promising candidate for developing treatments targeting conditions such as depression and cognitive dysfunction. Further research is needed to fully elucidate its mechanism of action and therapeutic efficacy.

Synthetic methodologies play a pivotal role in the accessibility and scalability of Benzyl 1-methyl-1H-indole-3-carboxylate. Recent reports have highlighted innovative synthetic routes that enhance yield and purity while minimizing environmental impact. These advancements are in line with the growing emphasis on sustainable chemistry practices within the pharmaceutical sector. By optimizing synthetic protocols, researchers can ensure a steady supply of high-quality material for both academic and industrial applications.

The role of Benzyl 1-methyl-1H-indole-3-carboxylate in medicinal chemistry extends beyond isolated applications; it serves as a building block for more complex molecules. Its structural features allow for seamless integration into larger scaffolds, facilitating the development of multi-target drugs. Such combinatorial approaches are increasingly favored in modern drug discovery due to their ability to address multiple aspects of a disease simultaneously, potentially leading to more effective treatments.

In conclusion, Benzyl 1-methyl-1H-indole-3-carboxylate (CAS No. 1033693-00-3) represents a fascinating compound with significant potential in pharmaceutical research. Its unique structural attributes, combined with recent advancements in synthetic and computational chemistry, position it as a valuable asset in the quest for novel therapeutic agents. As research continues to uncover new applications and refine synthetic methodologies, this compound is poised to play an increasingly important role in addressing various medical challenges.

• 108438-43-3(Methyl 1-methyl-1H-indole-3-carboxylate)
• 167479-21-2(methyl 1-methyl-1H-indole-7-carboxylate)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)