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Comprehensive Overview of (S)-Methyl (1-hydroxy-3-phenylpropan-2-yl)carbamate (CAS No. 10289-05-1)

(S)-Methyl (1-hydroxy-3-phenylpropan-2-yl)carbamate, with the CAS number 10289-05-1, is a chiral organic compound that has garnered significant attention in pharmaceutical and biochemical research. This compound, often referred to as a carbamate derivative, is characterized by its unique stereochemistry and functional groups, making it a valuable intermediate in the synthesis of bioactive molecules. The (S)-enantiomer configuration is particularly noteworthy due to its potential applications in asymmetric synthesis and drug development.

The growing interest in chiral building blocks like (S)-Methyl (1-hydroxy-3-phenylpropan-2-yl)carbamate aligns with current trends in green chemistry and sustainable synthesis. Researchers are increasingly focusing on enantioselective reactions to minimize waste and improve efficiency, which has led to a surge in demand for high-purity chiral compounds. This compound’s hydroxyl and carbamate functionalities make it versatile for further modifications, catering to applications in peptide synthesis, enzyme inhibitors, and pharmaceutical intermediates.

One of the most frequently asked questions about CAS No. 10289-05-1 revolves around its synthetic routes and scalability. Recent advancements in catalytic asymmetric hydrogenation and enzymatic resolution have provided more efficient pathways to produce this compound with high enantiomeric excess. These methods address the challenges of traditional synthesis, such as low yields and cumbersome purification steps, making (S)-Methyl (1-hydroxy-3-phenylpropan-2-yl)carbamate more accessible for industrial applications.

Another hot topic in the context of this compound is its role in drug discovery. The carbamate group is a common pharmacophore found in many FDA-approved drugs, contributing to enhanced stability and bioavailability. Researchers are exploring its potential in designing central nervous system (CNS) therapeutics and antiviral agents, leveraging its ability to interact with biological targets selectively. This has sparked discussions on platforms like PubMed and ResearchGate, where scientists share insights on its mechanistic studies.

From a commercial perspective, (S)-Methyl (1-hydroxy-3-phenylpropan-2-yl)carbamate is listed by several chemical suppliers as a high-value intermediate. Its pricing and availability are often queried in market reports, reflecting its importance in niche segments of the fine chemicals industry. Quality control parameters, such as HPLC purity and chiral HPLC analysis, are critical for buyers, emphasizing the need for reliable analytical methods to ensure consistency.

In summary, CAS No. 10289-05-1 represents a compelling case study in the intersection of chiral chemistry, process optimization, and applications in life sciences. Its relevance to contemporary research themes—such as sustainable catalysis, precision medicine, and material science—ensures its continued prominence in scientific literature and industrial workflows. Future studies may further elucidate its untapped potential, solidifying its status as a cornerstone in modern synthetic chemistry.

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