• 1. Nucleoside carbonyl(di- and triphosphates)
  Ivan B. Yanachkov,James M. Stattel,George E. Wright J. Chem. Soc. Perkin Trans. 1 2001 3080
• 2. The development of isoguanosine: from discovery, synthesis, and modification to supramolecular structures and potential applications
  Tingting Ding,Fan Tang,Guangcheng Ni,Jiang Liu,Hang Zhao,Qianming Chen RSC Adv. 2020 10 6223
• 3. Synthesis of pyrrolidine homoazasugars and 3,4-dihydroxy-5-hydroxymethylprolines using aldol additions of metalated bislactim ethers to 2,4-O-ethylidene-d-erythroses
  Olga Blanco,Cristina Pato,María Ruiz,Vicente Ojea Org. Biomol. Chem. 2009 7 2310
• 4. Inference of cancer mechanisms through computational systems analysis
  Zhen Qi,Eberhard O. Voit Mol. BioSyst. 2017 13 489
• 5. Design, synthesis and biological evaluation of bicyclic iminosugar hybrids: conformational constraint as an effective tool for tailoring the selectivity of α-glucosidase inhibitors
  Inderpreet Arora,Vivek Kr. Kashyap,Alok Kumar Singh,Arunava Dasgupta,Brijesh Kumar,Arun K. Shaw Org. Biomol. Chem. 2014 12 6855

• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine deoxyribonucleotides Purine deoxyribonucleoside diphosphates
• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Other Chemical Reagents

Comprehensive Overview of 2'-Deoxyguanosine-5'-diphosphate Trisodium Salt (CAS No. 102783-74-4)

2'-Deoxyguanosine-5'-diphosphate Trisodium Salt (CAS No. 102783-74-4) is a critical nucleotide derivative widely utilized in molecular biology, diagnostics, and pharmaceutical research. This compound, often abbreviated as dGDP Trisodium Salt, serves as a fundamental building block in DNA synthesis and repair mechanisms. Its unique chemical properties make it indispensable for applications such as PCR amplification, gene sequencing, and enzymatic studies. Researchers increasingly focus on its role in epigenetic modifications and cancer therapeutics, aligning with current trends in precision medicine.

The molecular structure of 2'-Deoxyguanosine-5'-diphosphate Trisodium Salt features a deoxyribose sugar moiety linked to a guanine base and two phosphate groups, stabilized by trisodium ions. This configuration enhances its solubility in aqueous solutions, a property highly valued in in vitro transcription and cell-free protein expression systems. Recent studies highlight its potential in CRISPR-Cas9 gene editing workflows, where nucleotide analogs improve editing efficiency—a topic dominating 2023-2024 scientific discussions.

Quality standards for CAS No. 102783-74-4 adhere to stringent pharmacopeial guidelines (USP/EP), ensuring batch-to-batch consistency for diagnostic kit manufacturers. The compound's stability under cryogenic storage (-20°C) makes it ideal for long-term biobanking, addressing growing demands in biomedical repositories. Analytical techniques like HPLC-UV and mass spectrometry confirm purity levels exceeding 98%, meeting requirements for NGS library preparation and qPCR assays.

Emerging applications include its use in mRNA vaccine development, where nucleotide analogs enhance immunogenicity. This connects with widespread public interest in vaccine technologies post-pandemic. Furthermore, the compound's role in telomerase research attracts attention for anti-aging studies—a frequently searched topic in AI-driven health forums. Manufacturers now offer isotope-labeled versions (¹³C/¹⁵N) for advanced metabolic pathway tracing studies.

From a regulatory perspective, dGDP Trisodium Salt complies with ISO 13485 standards for in vitro diagnostic applications. Its non-hazardous classification (per SDS documentation) facilitates global shipping without special permits. Current market analyses project 6.8% CAGR growth (2024-2030) for nucleotide reagents, driven by expansions in personalized medicine and synthetic biology—key phrases trending in scientific literature.

Best practices for handling recommend using RNase-free containers to prevent degradation, particularly for single-cell sequencing protocols. The compound's compatibility with reverse transcriptase enzymes makes it valuable for viral load testing, relevant to ongoing pathogen surveillance programs. Recent innovations include lyophilized formulations that improve shelf-life for point-of-care diagnostics in resource-limited settings.

In conclusion, 2'-Deoxyguanosine-5'-diphosphate Trisodium Salt (CAS No. 102783-74-4) represents a versatile tool at the forefront of life science innovation. Its evolving applications reflect interdisciplinary convergence between molecular biology, therapeutics, and diagnostic technology—addressing both current research priorities and future biomedical challenges.

• 56001-37-7([[(2R,3S,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-yl]methoxy-hydroxy-phosphoryl] phosphono hydrogen phosphate;sodium salt)
• 146-91-8(Guanosine 5'-Diphosphate)
• 24905-71-3(Guanosine 5'-(Tetrahydrogen triphosphate) Sodium Salt (>80%))
• 14356-96-8(Guanosine-5'-triphosphate tetrasodium salt)
• 7415-69-2(Guanosine 5'-Diphosphate Disodium Salt (>85%))
• 105184-12-1(Benzene,1,1'-(dichloroethenylidene)bis[4-chloro-, labeled with carbon-14 (9CI))
• 285978-17-8(Tetrasodium;[[[(2R,3S,4R,5R)-5-(2-(15N)azanyl-6-oxo-1H-purin-9-yl)-3,4-dihydroxy(2,3,4,5-13C4)oxolan-2-yl](113C)methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate)
• 43139-22-6(Guanosine 5'-diphosphate sodium salt)
• 36051-31-7(5'-GTP trisodium salt (Synonyms: Guanosine 5'-triphosphate trisodium salt))
• 18423-40-0(Guanosine5'-(tetrahydrogen triphosphate), 2'-deoxy-, sodium salt (9CI))