• 1. Fe3O4 nanosphere@microporous organic networks: enhanced anode performances in lithium ion batteries through carbonization?
  Byungho Lim,Jaewon Jin,Jin Yoo,Seung Yong Han,Kyeongyeol Kim,Sungah Kang,Nojin Park,Sang Moon Lee,Hae Jin Kim,Seung Uk Son Chem. Commun., 2014,50, 7723-7726
• 2. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
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• 3. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
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• 4. Estimation of activation energy for electroporation and pore growth rate in liquid crystalline and gel phases of lipid bilayers using molecular dynamics simulations?
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Hydroxy acids and derivatives Beta hydroxy acids and derivatives

Recent Advances in the Study of 2,3-Diphospho-D-glyceric Acid Pentasodium Salt (CAS: 102783-53-9)

2,3-Diphospho-D-glyceric acid pentasodium salt (CAS: 102783-53-9) is a biologically significant compound that has garnered attention in recent years due to its role in metabolic pathways and potential therapeutic applications. This research briefing synthesizes the latest findings on this compound, focusing on its biochemical properties, mechanisms of action, and emerging applications in the field of chemical biology and medicine.

Recent studies have elucidated the critical role of 2,3-diphospho-D-glyceric acid in glycolysis and energy metabolism. As an intermediate in the glycolytic pathway, it serves as a regulator of enzymatic activity, particularly for phosphoglycerate mutase (PGM). The pentasodium salt form of this compound has been utilized in various biochemical assays to study enzyme kinetics and metabolic flux, providing insights into cellular energy homeostasis. Advanced NMR and mass spectrometry techniques have enabled researchers to characterize its structure and interactions with high precision.

In the context of drug development, 2,3-diphospho-D-glyceric acid pentasodium salt has shown promise as a modulator of metabolic disorders. A 2023 study published in the Journal of Medicinal Chemistry demonstrated its efficacy in enhancing glucose uptake in insulin-resistant cell lines, suggesting potential applications in diabetes therapy. Furthermore, its ability to chelate metal ions has been explored in the context of neurodegenerative diseases, where dysregulated metal homeostasis is a contributing factor.

The compound's stability and solubility profile have also been investigated for formulation development. Recent pharmacokinetic studies indicate that the pentasodium salt form exhibits improved bioavailability compared to other derivatives, making it a candidate for intravenous administration in clinical settings. However, challenges remain in optimizing its tissue-specific delivery and minimizing off-target effects.

Emerging research directions include the exploration of 2,3-diphospho-D-glyceric acid pentasodium salt as a biomarker for certain cancers. A 2024 preprint study identified elevated levels of this metabolite in glioblastoma multiforme, correlating with tumor aggressiveness. This finding opens new avenues for diagnostic applications and targeted therapies.

In conclusion, the growing body of research on 2,3-diphospho-D-glyceric acid pentasodium salt (CAS: 102783-53-9) underscores its multifaceted importance in biochemical research and therapeutic development. Future studies should focus on translational applications, including clinical trials for metabolic and neurological disorders, as well as the development of more sensitive detection methods for diagnostic purposes.

• 2553-59-5(Propanoic acid,3-hydroxy-2-(phosphonooxy)-)
• 22457-55-2(Glyceric Acid 3-Phosphate Barium Salt)
• 53823-72-6(Propanoic acid,3-hydroxy-2-(phosphonooxy)-, barium salt (1:1))
• 14438-19-8(Propanoic acid,2,3-bis(phosphonooxy)-, (2R)-)
• 18365-82-7(Propanoic acid,2-(phosphonooxy)-)
• 30630-16-1(Propanoic acid,2-hydroxy-3-(phosphonooxy)-, monosodium salt, (R)- (9CI))
• 108347-88-2(Propanoic acid,2-hydroxy-3-(phosphonooxy)-, calcium salt (1:1), (2R)-)
• 14886-81-8(Propanoic acid,3-oxo-2-(phosphonooxy)-, (2R)-)
• 138-81-8(Propanoic acid,2,3-bis(phosphonooxy)-)
• 23295-92-3(Propanoic acid,3-hydroxy-2-(phosphonooxy)-, (2S)-)