• 1. An interplay between electronic and structural effects on the photoluminescence decay mechanisms in LaPO4·nH2O:Tb3+ and LaPO4:Tb3+ single-crystal nanorods?
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• 2. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
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• 3. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 4. An anti-ultrasonic-stripping effect in confined micro/nanoscale cavities and its applications for efficient multiscale metallic patterning?
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• 5. An artificial blood vessel implanted three-dimensional microsystem for modeling transvascular migration of tumor cells?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Nitrobenzenes

Methyl 3-nitrophenylacetate (CAS No. 10268-12-9): A Comprehensive Overview

Methyl 3-nitrophenylacetate, identified by its Chemical Abstracts Service (CAS) number 10268-12-9, is a compound of significant interest in the field of organic chemistry and pharmaceutical research. This ester derivative of phenylacetic acid features a nitro group at the para position, which imparts unique chemical properties and reactivity. The compound has garnered attention due to its potential applications in synthetic chemistry, as a building block for more complex molecules, and its role in various biochemical pathways.

The structural characteristics of Methyl 3-nitrophenylacetate make it a versatile intermediate in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. The presence of the nitro group enhances its reactivity, allowing for further functionalization through reduction to an amine or further derivatization. This flexibility is particularly valuable in drug discovery, where rapid and efficient synthesis of novel compounds is crucial.

In recent years, Methyl 3-nitrophenylacetate has been explored in the development of novel therapeutic agents. Its derivatives have shown promise in various preclinical studies, particularly in the area of anti-inflammatory and analgesic drugs. The nitro group can be readily converted into other functional groups, such as hydroxyl or carboxylic acids, which are common motifs in many bioactive molecules.

The compound's role in synthetic chemistry extends beyond pharmaceutical applications. It serves as a key intermediate in the preparation of more complex organic molecules, including dyes, polymers, and advanced materials. The ability to modify the nitro group allows chemists to fine-tune the properties of these materials, making Methyl 3-nitrophenylacetate a valuable tool in industrial chemistry.

Recent advancements in green chemistry have also highlighted the importance of Methyl 3-nitrophenylacetate as a sustainable building block. Researchers have developed environmentally friendly synthetic routes to produce this compound, minimizing waste and reducing the use of hazardous reagents. These methods align with the growing emphasis on sustainable practices in chemical manufacturing.

The biochemical significance of Methyl 3-nitrophenylacetate lies in its potential to interact with biological targets. Studies have suggested that derivatives of this compound may modulate enzyme activity and signal transduction pathways, offering insights into new therapeutic strategies. For instance, researchers have investigated its potential role in inhibiting certain enzymes associated with inflammation and pain perception.

The pharmacokinetic properties of Methyl 3-nitrophenylacetate and its derivatives are also areas of active research. Understanding how these compounds are metabolized and eliminated from the body is crucial for developing effective drugs. Advanced analytical techniques, such as mass spectrometry and nuclear magnetic resonance (NMR) spectroscopy, have been employed to study these processes in detail.

In conclusion, Methyl 3-nitrophenylacetate (CAS No. 10268-12-9) is a multifaceted compound with broad applications in synthetic chemistry and pharmaceutical research. Its unique structural features and reactivity make it a valuable intermediate for developing novel drugs and materials. As research continues to uncover new applications for this compound, its importance in the chemical industry is likely to grow.

• 14318-64-0(Ethyl 2-(3-nitrophenyl)acetate)
• 5445-26-1(Ethyl (4-Nitrophenyl)acetate)
• 50415-69-5(Methyl 2-(4-Nitrophenyl)propanoate)
• 29704-38-9(Benzeneacetic acid,4-nitro-, 1,1-dimethylethyl ester)
• 481065-73-0(Benzeneacetic acid, 4-ethyl-2-nitro-, methyl ester (9CI))
• 68527-46-8(m-nitrophenethyl acetate)
• 1877-73-2(2-(3-nitrophenyl)acetic acid)
• 287119-84-0(Methyl 2-(2-methyl-5-nitrophenyl)acetate)
• 2945-08-6(Methyl 2-(4-nitrophenyl)acetate)
• 50712-66-8(Ethyl 2-(2-methyl-4-nitrophenyl)acetate)