Cas no 102677-74-7 (5-(Aminomethyl)-2-chloroaniline dihydrochloride)

5-(Aminomethyl)-2-chloroaniline dihydrochloride is a chemically stable, high-purity intermediate widely used in pharmaceutical synthesis and organic research. Its dihydrochloride form enhances solubility in aqueous systems, facilitating reactions in polar solvents. The compound features both an aminomethyl and a chloro substituent on the aromatic ring, making it a versatile building block for constructing complex molecules, particularly in the development of active pharmaceutical ingredients (APIs). Its well-defined structure and consistent reactivity ensure reliable performance in coupling reactions and derivatization processes. Suitable for controlled environments, it is typically handled under inert conditions to preserve stability. Available in research-grade purity, it meets stringent quality standards for synthetic applications.
5-(Aminomethyl)-2-chloroaniline dihydrochloride structure
102677-74-7 structure
Product Name:5-(Aminomethyl)-2-chloroaniline dihydrochloride
CAS No:102677-74-7
MF:C7H11Cl3N2
MW:229.534638643265
CID:125194
PubChem ID:13465098
Update Time:2025-06-08

5-(Aminomethyl)-2-chloroaniline dihydrochloride Chemical and Physical Properties

Names and Identifiers

    • 5-(Aminomethyl)-2-chloroaniline dihydrochloride
    • 3-AMINO-4-CHLORO-BENZENEMETHANAMINE DIHYDROCHLORIDE
    • Benzenemethanamine,3-amino-4-chloro-, hydrochloride (1:2)
    • 3-amino-4-chlorobenzylamine dihydrochloride
    • 4-CHLORO-3-AMINOBENZENE-METHANAMINE DIHYDROCHLORIDE
    • 5-(aminomethyl)-2-chloroanilinedihydrochloride
    • 3-amino-4-chlorobenzenemethanamine dihydrochloride
    • Z1480642430
    • EN300-114028
    • FT-0721179
    • CS-0223132
    • 5-(Aminomethyl)-2-chloroaniline--hydrogen chloride (1/2)
    • SB80569
    • 5-(aminomethyl)-2-chloroaniline;dihydrochloride
    • 102677-74-7
    • AKOS015909091
    • DTXSID40541523
    • Inchi： 1S/C7H9ClN2.2ClH/c8-6-2-1-5(4-9)3-7(6)10;;/h1-3H,4,9-10H2;2*1H
    • InChI Key： GGRUHFCZFKLAJR-UHFFFAOYSA-N
    • SMILES： ClC1C=CC(=CC=1N)CN.Cl.Cl

Computed Properties

  • Exact Mass: 227.99900
  • Monoisotopic Mass: 227.998781g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 4
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 1
  • Complexity: 108
  • Covalently-Bonded Unit Count: 3
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 52?2

Experimental Properties

  • Density: g/cm3
  • Boiling Point: 344.6°Cat760mmHg
  • Flash Point: 162.2°C
  • PSA: 52.04000
  • LogP: 4.26640

5-(Aminomethyl)-2-chloroaniline dihydrochloride Customs Data

  • HS CODE：2921590090
  • Customs Data：

    China Customs Code:

    2921590090

    Overview:

    2921590090. Other aromatic polyamines and derivatives and their salts. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2921590090. other aromatic polyamines and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

5-(Aminomethyl)-2-chloroaniline dihydrochloride Pricemore >>

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5-(Aminomethyl)-2-chloroaniline dihydrochloride Related Literature

Additional information on 5-(Aminomethyl)-2-chloroaniline dihydrochloride

Comprehensive Overview of 5-(Aminomethyl)-2-chloroaniline dihydrochloride (CAS No. 102677-74-7): Properties, Applications, and Industry Insights

5-(Aminomethyl)-2-chloroaniline dihydrochloride (CAS No. 102677-74-7) is a specialized organic compound widely utilized in pharmaceutical intermediates, agrochemical synthesis, and advanced material research. This compound, characterized by its aminomethyl and chloroaniline functional groups, has garnered significant attention due to its versatility in chemical transformations. With the rise of precision medicine and sustainable agriculture, researchers are increasingly exploring its potential in targeted drug delivery systems and eco-friendly crop protection solutions.

The molecular structure of 5-(Aminomethyl)-2-chloroaniline dihydrochloride features a benzene ring substituted with both a chloro group and an aminomethyl moiety, which enhances its reactivity in nucleophilic substitution reactions. This makes it a valuable building block for synthesizing complex molecules, particularly in the development of heterocyclic compounds and bioconjugates. Recent studies highlight its role in creating fluorescent probes for bioimaging, addressing the growing demand for non-invasive diagnostic tools in healthcare.

From an industrial perspective, the compound's stability under controlled conditions and compatibility with green chemistry principles align with global trends toward sustainable manufacturing. Innovations in catalytic processes have reduced the environmental footprint of its production, resonating with the circular economy initiatives prioritized by regulatory bodies. Furthermore, its application in polymer modification has opened doors to high-performance materials used in electronics and coatings, answering the call for energy-efficient technologies.

Quality control of 5-(Aminomethyl)-2-chloroaniline dihydrochloride adheres to stringent protocols, ensuring purity levels exceeding 98% for research-grade batches. Analytical techniques such as HPLC and NMR spectroscopy are routinely employed to verify its structural integrity, a critical factor for reproducibility in academic and industrial settings. As synthetic biology advances, this compound is also being investigated for enzyme-mediated transformations, tapping into the burgeoning field of biocatalysis.

Market analysts note a steady increase in demand for CAS 102677-74-7, driven by its expanding role in personalized medicine and smart materials. Its compatibility with continuous flow chemistry systems has further streamlined large-scale production, reducing costs and waste generation. For researchers seeking reliable sources, third-party certifications like ISO 9001 and REACH compliance serve as key indicators of supplier credibility.

In summary, 5-(Aminomethyl)-2-chloroaniline dihydrochloride exemplifies the convergence of chemical innovation and industrial applicability. Its multifaceted uses—from life sciences to advanced materials—position it as a compound of enduring relevance in an era defined by technological advancement and sustainability imperatives.

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