• 1. Emerging investigator series: bacteriophages as nano engineering tools for quality monitoring and pathogen detection in water and wastewater
  Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
• 2. Evolution of calcium phosphate precipitation in hanging drop vapor diffusion by in situRaman microspectroscopy
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• 3. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
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• 4. Esterase-responsive polymeric prodrug-based tumor targeting nanoparticles for improved anti-tumor performance against colon cancer?
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• 5. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
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Recent Advances in the Application of (6-Chloropyrimidin-4-yl)methanol (CAS: 1025351-41-0) in Chemical Biology and Pharmaceutical Research

(6-Chloropyrimidin-4-yl)methanol (CAS: 1025351-41-0) is a key intermediate in the synthesis of various biologically active compounds, particularly in the development of kinase inhibitors and other therapeutic agents. Recent studies have highlighted its versatility as a building block in medicinal chemistry, enabling the construction of complex molecular architectures with potential pharmacological applications. This research brief synthesizes the latest findings on this compound, focusing on its synthetic utility, biological relevance, and emerging applications in drug discovery.

A 2023 study published in the Journal of Medicinal Chemistry demonstrated the efficient use of (6-Chloropyrimidin-4-yl)methanol in the synthesis of novel Bruton's tyrosine kinase (BTK) inhibitors. The researchers developed a concise synthetic route where this compound served as a crucial intermediate, allowing for the introduction of various substituents at the 4-position of the pyrimidine ring. The resulting compounds showed promising activity against BTK, with IC50 values in the low nanomolar range, suggesting potential applications in treating B-cell malignancies and autoimmune diseases.

In the field of antimicrobial research, a recent publication in Bioorganic & Medicinal Chemistry Letters (2024) reported the incorporation of (6-Chloropyrimidin-4-yl)methanol into novel hybrid molecules targeting bacterial DNA gyrase. The study found that derivatives containing this scaffold exhibited potent activity against multidrug-resistant Staphylococcus aureus strains, with MIC values comparable to current frontline antibiotics. Molecular docking studies revealed that the chloropyrimidine moiety plays a critical role in binding to the ATPase domain of gyrase, providing insights for further optimization.

Recent advancements in synthetic methodology have expanded the utility of (6-Chloropyrimidin-4-yl)methanol. A 2024 Nature Protocols paper detailed a robust, scalable synthesis of this compound with improved yield and purity, addressing previous challenges in large-scale production. The protocol employs a novel protecting group strategy that minimizes side reactions and facilitates downstream functionalization, making the compound more accessible for pharmaceutical development.

Emerging applications in targeted protein degradation have also been reported. Researchers at a major pharmaceutical company recently disclosed (2024) the use of (6-Chloropyrimidin-4-yl)methanol-derived PROTACs (proteolysis targeting chimeras) for selective degradation of disease-relevant proteins. The compound's ability to serve as a linker between target-binding and E3 ligase-recruiting moieties was particularly noted, with several candidates showing promising preclinical results in cancer models.

Ongoing clinical trials involving compounds derived from (6-Chloropyrimidin-4-yl)methanol suggest growing pharmaceutical interest in this scaffold. Two phase I trials for oncology indications and one phase II trial for inflammatory diseases are currently recruiting patients, according to recent ClinicalTrials.gov updates. These developments underscore the compound's importance as a versatile pharmacophore in modern drug discovery.

In conclusion, (6-Chloropyrimidin-4-yl)methanol (CAS: 1025351-41-0) continues to demonstrate significant value in chemical biology and pharmaceutical research. Its applications span from kinase inhibitor development to antimicrobial agents and innovative modalities like PROTACs. The recent methodological improvements in its synthesis and the promising biological activities of its derivatives suggest this compound will remain an important tool in medicinal chemistry for the foreseeable future.

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• 1037543-27-3(2,4-Dichloro-6-(methoxymethyl)pyrimidine)
• 914802-11-2(4-[(benzyloxy)methyl]-6-chloropyrimidine)