• 1. An atomically efficient, highly stable and redox active Ce0.5Tb0.5Ox (3% mol.)/MgO catalyst for total oxidation of methane?
  Juan J. Sánchez,Miguel López-Haro,Juan C. Hernández-Garrido,Ginesa Blanco,Miguel A. Cauqui,José M. Rodríguez-Izquierdo,José A. Pérez-Omil,José J. Calvino,María P. Yeste J. Mater. Chem. A, 2019,7, 8993-9003
• 2. Alternative synthesis of the anti-baldness compound RU58841?
  RSC Adv., 2014,4, 14143-14148
• 3. An analysis of the WTC fires using CIB correlations and simple modeling
  JGQuintiere
• 4. An atmosphere and light tuned highly diastereoselective synthesis of cyclobuta/penta[b]indoles from aniline-tethered alkylidenecyclopropanes with alkynes?
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• 5. An all-solid-state asymmetric device based on a polyaniline hydrogel for a high energy flexible supercapacitor?
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters

Methyl 2-hydroxy-6-(trifluoromethyl)benzoate (CAS No. 1024605-95-5): A Comprehensive Overview

Methyl 2-hydroxy-6-(trifluoromethyl)benzoate, identified by the CAS number 1024605-95-5, is a compound of significant interest in various fields, including pharmaceuticals, agrochemicals, and materials science. This compound is characterized by its unique structure, which includes a benzoate backbone substituted with a hydroxyl group at the 2-position and a trifluoromethyl group at the 6-position. The trifluoromethyl group imparts distinctive electronic and steric properties, making this compound a valuable building block in organic synthesis.

The synthesis of Methyl 2-hydroxy-6-(trifluoromethyl)benzoate typically involves multi-step processes, often starting from aromatic precursors. Recent advancements in catalytic methods have enabled more efficient and selective syntheses, reducing production costs and environmental impact. For instance, the use of palladium-catalyzed cross-coupling reactions has been reported to facilitate the introduction of the trifluoromethyl group with high precision.

In terms of applications, Methyl 2-hydroxy-6-(trifluoromethyl)benzoate has shown promise in drug discovery programs targeting various diseases. Its hydroxyl group provides opportunities for bioisosteric replacements, while the trifluoromethyl group enhances lipophilicity and metabolic stability—key attributes for drug candidates. Recent studies have highlighted its potential as a lead compound in anti-inflammatory and anticancer drug development.

The physical and chemical properties of Methyl 2-hydroxy-6-(trifluoromethyl)benzoate are well-documented. Its melting point is approximately 110°C, and it exhibits moderate solubility in common organic solvents such as dichloromethane and ethyl acetate. The presence of electron-withdrawing groups like the trifluoromethyl group significantly influences its reactivity in various chemical transformations.

From an environmental perspective, the degradation pathways of Methyl 2-hydroxy-6-(trifluoromethyl)benzoate have been studied to assess its ecological impact. Research indicates that under aerobic conditions, the compound undergoes microbial degradation, albeit at a slower rate compared to simpler aromatic compounds. This information is crucial for risk assessment and sustainable chemical management practices.

In conclusion, Methyl 2-hydroxy-6-(trifluoromethyl)benzoate (CAS No. 1024605-95-5) stands out as a versatile compound with diverse applications across multiple disciplines. Its unique structure, coupled with recent advancements in synthesis and application techniques, positions it as a key player in modern chemical research and development.

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