• 1. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 2. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 3. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 4. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126
• 5. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Halobenzoic acids and derivatives

2-Bromo-4-chlorobenzhydrazide (CAS No. 1023334-50-0): A Versatile Intermediate in Pharmaceutical and Chemical Synthesis

2-Bromo-4-chlorobenzhydrazide, with the chemical formula C₇H₅BrClN₂O₂, is a pivotal compound in modern chemical synthesis, particularly in the development of pharmaceuticals and functional materials. Its CAS No. 1023334-50-0 serves as a unique identifier for this compound, reflecting its distinct chemical structure and properties. This molecule combines halogen atoms (bromine and chlorine) with a hydrazide functional group, creating a versatile platform for the synthesis of diverse bioactive compounds. Recent advancements in medicinal chemistry have highlighted its potential as a key intermediate in drug discovery, particularly in the design of molecules targeting inflammatory pathways and neurodegenerative diseases.

The 2-Bromo-4-chlorobenzhydrazide structure features a benzene ring substituted with bromine at the 2-position and chlorine at the 4-position, with hydrazide groups at the 1-position. This configuration allows for multiple reaction sites, enabling the formation of complex scaffolds through nucleophilic substitution, condensation, and electrophilic aromatic substitution reactions. The presence of both halogen atoms and the hydrazide functionality makes it a valuable reagent for the synthesis of heterocyclic compounds, which are prevalent in modern drug development. For instance, a 2023 study published in *Organic & Biomolecular Chemistry* demonstrated the utility of 2-Bromo-4-chlorobenzhydrazide in the preparation of pyrazole derivatives with enhanced anti-inflammatory activity.

Recent research has focused on optimizing the synthetic pathways for 2-Bromo-4-chlorobenzhydrazide to improve yield and purity. A 2022 paper in *Green Chemistry* reported a novel microwave-assisted synthesis method that reduced reaction time by 40% while maintaining high selectivity. This advancement aligns with the growing emphasis on sustainable chemical processes, which is critical for reducing environmental impact in pharmaceutical manufacturing. The CAS No. 1023334-50-0 compound has also been explored as a building block for the synthesis of metal-organic frameworks (MOFs), which are used in catalysis and gas storage applications. These applications underscore the broad utility of 2-Bromo-4-chlorobenzhydrazide beyond traditional pharmaceutical contexts.

One of the most promising areas for 2-Bromo-4-chlorobenzhydrazide is its role in the development of small-molecule therapeutics. A 2023 study in *Journal of Medicinal Chemistry* highlighted its use in the synthesis of a novel class of antiviral agents targeting the SARS-CoV-2 virus. The hydrazide group was found to enhance the binding affinity of the resulting compounds to viral proteases, a critical factor in the efficacy of antiviral drugs. This application exemplifies how 2-Bromo-4-chlorobenzhydrazide can be tailored to address specific therapeutic challenges, leveraging its chemical versatility to create molecules with improved pharmacokinetic profiles.

Another significant area of research involves the use of 2-Bromo-4-chlorobenzhydrazide in the design of targeted drug delivery systems. A 2023 publication in *Advanced Drug Delivery Reviews* described a strategy to functionalize this compound with polyethylene glycol (PEG) chains, enabling the creation of long-circulating nanoparticles for cancer therapy. The hydrazide functionality was exploited to form covalent bonds with the PEG chains, ensuring stability in biological environments while allowing controlled release of the therapeutic payload. This application demonstrates the adaptability of 2-Bromo-4-chlorobenzhydrazide in advanced pharmaceutical technologies.

The CAS No. 1023334-50-0 compound has also been investigated for its potential in the synthesis of optoelectronic materials. A 2022 study in *Advanced Functional Materials* reported the use of 2-Bromo-4-chlorobenzhydrazide as a precursor for the preparation of organic light-emitting diodes (OLEDs). The compound's ability to form conjugated systems with high charge mobility made it an effective material for enhancing the efficiency of OLED devices. This application highlights the cross-disciplinary relevance of 2-Bromo-4-chlorobenzhydrazide, bridging the gap between chemical synthesis and advanced materials science.

Despite its growing importance, the synthesis of 2-Bromo-4-chlorobenzhydrazide remains a challenge due to the need for precise control over reaction conditions. A 2023 review in *Chemical Society Reviews* summarized the latest strategies for overcoming these challenges, including the use of catalytic systems and solvent engineering. These approaches not only improve the efficiency of 2-Bromo-4-chlorobenzhydrazide synthesis but also reduce the environmental footprint of the process, aligning with global efforts to promote green chemistry.

In conclusion, 2-Bromo-4-chlorobenzhydrazide (CAS No. 1023334-50-0) represents a critical intermediate in the development of innovative pharmaceuticals and functional materials. Its unique chemical structure enables a wide range of synthetic transformations, making it a valuable tool for researchers in diverse fields. As ongoing studies continue to uncover new applications for this compound, its role in modern chemistry is likely to expand further, driving advancements in both therapeutic and industrial contexts.

• 791717-65-2(1,4-Benzenedicarboxylic acid, 2,5-dibromo-, dihydrazide)
• 1022059-55-7(Benzoic acid, 2-bromo-4-methyl-, hydrazide)
• 148672-43-9(4-Bromo-3-methyl-benzoic Acid Hydrazide)
• 148993-19-5(4-Bromo-3-chlorobenzhydrazide)
• 66073-53-8(2-Chloro-6-bromobenzamide)
• 791717-66-3(Benzoic acid, 2,5-dibromo-4-methyl-, hydrazide)
• 29418-67-5(2-Bromobenzhydrazide)
• 148993-18-4(3-Bromo-4-chlorobenzohydrazide)
• 206559-39-9(4-Bromo-2-chlorobenzhydrazide)
• 1023565-25-4(2-Bromo-5-chlorobenzhydrazide)