• 1. Evolutionary approaches in protein engineering towards biomaterial construction
  Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
• 2. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 3. Excellent energy storage performance in NaNbO3-based relaxor antiferroeic ceramics under a low electric field
  XuxinCheng,XiaomingChen,PengyuanFan
• 4. Fate of single walled carbon nanotubes in wetland ecosystems?
  Joseph H. Bisesi,Tara Sabo-Attwood Environ. Sci.: Nano, 2014,1, 574-583
• 5. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Aralkylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Aralkylamines

Comprehensive Guide to 3-methyl-N-(propan-2-yl)aniline (CAS No. 10219-26-8): Properties, Applications, and Industry Insights

3-methyl-N-(propan-2-yl)aniline, with the CAS number 10219-26-8, is a specialized organic compound widely utilized in pharmaceutical intermediates, agrochemical synthesis, and advanced material research. This aromatic amine derivative features a methyl group at the 3-position of the benzene ring and an isopropylamino substituent, granting it unique reactivity in N-alkylation reactions and catalytic processes. Its molecular structure (C₁₀H₁₅N) balances lipophilicity and steric effects, making it valuable for designing bioactive molecules.

Recent studies highlight its role in developing non-steroidal anti-inflammatory drug (NSAID) precursors, aligning with the growing demand for sustainable pain management solutions. Researchers are investigating its potential in photocatalysis and green chemistry applications, particularly in solvent-free reactions—a trending topic in environmentally friendly synthesis. The compound’s logP value (~2.8) suggests moderate hydrophobicity, ideal for optimizing drug bioavailability, a key focus in pharmacokinetic research.

Industrially, 10219-26-8 serves as a building block for liquid crystal materials and OLED intermediates, addressing the surge in flexible display technologies. Analytical techniques like HPLC-MS and NMR spectroscopy confirm its high purity (>98%), critical for electronic-grade applications. Safety data sheets emphasize proper handling under REACH compliance, though it’s classified as non-hazardous under standard conditions—a detail frequently queried in regulatory chemistry forums.

Innovative applications include its use in metal-organic frameworks (MOFs) for gas storage, leveraging its nitrogen donor sites. Patent analyses reveal a 20% increase in filings involving this compound since 2020, particularly in battery electrolyte additives—an area gaining traction with electric vehicle (EV) advancements. Its thermal stability (decomposition >250°C) also makes it suitable for high-performance polymer modifiers.

For laboratory synthesis, optimized routes via Buchwald-Hartwig coupling or reductive amination achieve yields exceeding 85%. Suppliers often highlight its cost-efficiency compared to analogous anilines, a frequent comparison in procurement discussions. Storage recommendations include amber glass under inert gas, addressing stability concerns raised in chemical storage best practices searches.

Emerging research explores its antimicrobial derivatives, responding to the global focus on antibiotic resistance. Computational models predict strong binding affinity to bacterial efflux pumps, positioning it as a candidate for next-generation disinfectant formulations. These developments align with WHO priority pathogen lists, making it a compound of interest in public health chemistry.

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