• 1. Excitonic channels from bio-inspired templated supramolecular assembly of J-aggregate nanowires?
  Daniel Messmer,Stefan Salentinig,Jakob Heier Nanoscale, 2019,11, 6929-6938
• 2. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
• 3. Emergence of cationic polyamine dendrimersomes: design, stimuli sensitivity and potential biomedical applications
  Partha Laskar,Christine Dufès Nanoscale Adv., 2021,3, 6007-6026
• 4. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 5. Fe3O4 nanoclusters highly dispersed on a porous graphene support as an additive for improving the hydrogen storage properties of LiBH4?
  Guang Xu,Wei Zhang,Ying Zhang,Xiaoxia Zhao,Ping Wen,Di Ma RSC Adv., 2018,8, 19353-19361

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Alkyl aryl ethers

Ancitabine Hydrochloride (CAS No. 10212-25-6): A Comprehensive Overview of Its Properties and Applications

Ancitabine hydrochloride (CAS No. 10212-25-6) is a synthetic nucleoside analog with significant relevance in biomedical research and therapeutic development. This compound, also known as 2'-deoxy-2'-methylidenecytidine hydrochloride, belongs to the class of cytidine derivatives and has been extensively studied for its unique biochemical properties. Its molecular formula is C₉H₁₂N₃O₄·HCl, and it exhibits a molecular weight of 261.67 g/mol. The compound is characterized by its white to off-white crystalline powder appearance and high solubility in water, making it suitable for various pharmaceutical formulations.

In recent years, Ancitabine hydrochloride has garnered attention due to its potential role in cancer research and antiviral studies. As a nucleoside analog, it functions by interfering with DNA and RNA synthesis, a mechanism that aligns with current trends in targeted therapy and precision medicine. Researchers are particularly interested in its ability to modulate cellular processes, which could lead to breakthroughs in treating diseases with high unmet medical needs. This aligns with the growing public interest in personalized medicine and innovative therapeutics, topics frequently searched in academic and medical databases.

The synthesis of Ancitabine hydrochloride involves sophisticated organic chemistry techniques, including phosphorylation and glycosylation reactions. Its purity and stability are critical factors for research applications, prompting rigorous quality control protocols. Analytical methods such as HPLC (High-Performance Liquid Chromatography) and NMR (Nuclear Magnetic Resonance) spectroscopy are commonly employed to verify its structural integrity. These aspects resonate with the increasing demand for high-purity research chemicals, a frequently searched term among scientists and procurement specialists.

From a pharmacological perspective, Ancitabine hydrochloride has shown promise in preclinical studies for its antiproliferative effects. Its mechanism of action involves incorporation into nucleic acids, leading to chain termination—a property shared with other clinically approved antimetabolites. This has sparked discussions about its potential as a chemotherapeutic agent, particularly in combination therapies. Such investigations are timely, given the global focus on cancer treatment advancements and combination drug strategies, which dominate current medical literature and search engine queries.

Beyond oncology, Ancitabine hydrochloride is being explored for its immunomodulatory properties. Preliminary data suggest it may influence cytokine production and immune cell function, making it relevant to autoimmune disease research. This aligns with the rising interest in immune system modulation and novel immunotherapies, topics that frequently appear in both scientific publications and public health discussions. The compound's versatility underscores its value across multiple research domains.

In the context of drug development, Ancitabine hydrochloride serves as an important reference compound for structure-activity relationship (SAR) studies. Medicinal chemists utilize it to design new analogs with improved pharmacokinetic profiles and reduced side effects. This application taps into the growing field of computational chemistry and molecular modeling, areas experiencing rapid growth due to advancements in artificial intelligence and machine learning applications in drug discovery—a hot topic in both academic and industry circles.

The stability of Ancitabine hydrochloride under various storage conditions is another area of practical importance. Research indicates that the compound remains stable when stored at -20°C in airtight containers protected from light and moisture. This information is crucial for laboratories focusing on long-term compound storage and sample integrity, concerns frequently raised in research forums and quality assurance discussions.

From a regulatory standpoint, Ancitabine hydrochloride is classified as a research chemical intended for laboratory use only. Its handling requires standard laboratory safety protocols, including the use of personal protective equipment (PPE) and proper ventilation. These precautions reflect the broader scientific community's emphasis on research safety and responsible chemical management, subjects that consistently rank high in institutional training programs and occupational health guidelines.

The global market for nucleoside analogs like Ancitabine hydrochloride continues to expand, driven by increasing investment in biopharmaceutical research and drug discovery. Market analyses predict sustained growth in this sector, particularly in regions with strong biotechnology infrastructure. This economic perspective connects with frequent searches about research chemical markets and pharmaceutical industry trends, providing valuable context for business analysts and research directors alike.

Looking ahead, the scientific community anticipates further characterization of Ancitabine hydrochloride's biological activities through advanced omics technologies such as genomics and proteomics. These approaches align with current movements toward systems biology and multi-omics integration in biomedical research. The compound's potential applications in epigenetic modulation and gene expression studies represent particularly exciting frontiers that mirror the scientific community's growing fascination with epigenetics and gene regulation mechanisms.

In conclusion, Ancitabine hydrochloride (CAS No. 10212-25-6) stands as a versatile and scientifically valuable compound with diverse research applications. Its relevance spans from basic biochemical research to potential therapeutic development, reflecting the compound's multifaceted nature. As scientific understanding evolves and technological capabilities advance, Ancitabine hydrochloride will likely continue to play a significant role in addressing some of the most pressing challenges in modern medicine and biology.

• 37717-21-8(Flurocitabine)
• 31501-46-9(2,2'-Anhydro-L-uridine)
• 31698-14-3(Ancitabine)
• 53758-33-1(Dodecanoic acid,[2,3,3a,9a-tetrahydro-6-imino-3-[(1-oxododecyl)oxy]-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-2-yl]methylester, monohydrochloride, [2R-(2a,3b,3ab,9ab)]- (9CI))
• 64130-39-8(Tricyclo[3.3.1.13,7]decane-1-carboxylicacid,[2,3,3a,9a-tetrahydro-6-imino-3-[(tricyclo[3.3.1.13,7]dec-1-ylcarbonyl)oxy]-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-2-yl]methylester, monohydrochloride, [2R-(2a,3b,3ab,9ab)]- (9CI))
• 3736-77-4(2,2'-Anhydrouridine)
• 32659-29-3(6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-ol,2-(chloromethyl)-2,3,3a,9a-tetrahydro-6-imino-, hydrochloride (1:1),(2S,3S,3aS,9aR)-)
• 25878-33-5(6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidine-2-methanol,2,3,3a,9a-tetrahydro-6-imino-3-(phosphonooxy)-, (2R,3R,3aS,9aR)-)
• 53758-27-3(Octadecanoic acid, 2,3,3a,9a-tetrahydro-2-(hydroxymethyl)-6-imino-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-yl ester, monohydrochloride,[2R-(2a,3b,3ab,9ab)]- (9CI))
• 53758-26-2(Tetradecanoicacid,2,3,3a,9a-tetrahydro-2-(hydroxymethyl)-6-imino-6H-furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-3-ylester, monohydrochloride, [2R-(2a,3b,3ab,9ab)]- (9CI))