• 1. An arsenic trioxide nanoparticle prodrug (ATONP) potentiates a therapeutic effect on an aggressive hepatocellular carcinoma model via enhancement of intratumoral arsenic accumulation and disturbance of the tumor microenvironment?
  Xin Fu,Qing-rong Liang,Rong-guang Luo,Yan-shu Li,Xiao-ping Xiao,Lu-lu Yu,Wen-zhe Shan,Guang-qin Fan J. Mater. Chem. B, 2019,7, 3088-3099
• 2. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 3. An approach to biodegradable star polymeric architectures using disulfide coupling?
  Jingquan Liu,Huiyun Liu,Zhongfan Jia,Volga Bulmus,Thomas P. Davis Chem. Commun., 2008, 6582-6584
• 4. An apparatus for testing water by measurement of its electrical conductivity
  Analyst, 1912,37, 538-543
• 5. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides

Comprehensive Overview of 4-Bromo-N-butyl-3-(trifluoromethyl)benzenesulfonamide (CAS No. 1020253-05-7)

4-Bromo-N-butyl-3-(trifluoromethyl)benzenesulfonamide (CAS No. 1020253-05-7) is a specialized sulfonamide derivative with significant applications in pharmaceutical and agrochemical research. This compound, characterized by its bromine and trifluoromethyl functional groups, has garnered attention for its unique chemical properties and potential in drug discovery. Researchers often explore its role as a building block in organic synthesis, particularly in the development of bioactive molecules targeting enzyme inhibition or receptor modulation.

The molecular structure of 4-Bromo-N-butyl-3-(trifluoromethyl)benzenesulfonamide features a benzenesulfonamide core substituted with a bromine atom at the 4-position and a trifluoromethyl group at the 3-position. The N-butyl side chain enhances its lipophilicity, making it suitable for studies involving membrane permeability and drug delivery systems. This compound is frequently referenced in patents and scientific literature related to kinase inhibitors and anti-inflammatory agents, aligning with current trends in precision medicine and targeted therapies.

In the context of green chemistry, 4-Bromo-N-butyl-3-(trifluoromethyl)benzenesulfonamide is often discussed for its potential in sustainable synthesis routes. With growing interest in environmentally friendly chemical processes, researchers are investigating catalytic methods to reduce waste and energy consumption during its production. This aligns with the broader industry shift toward ESG (Environmental, Social, and Governance) compliance, a topic frequently searched by professionals in the chemical sector.

The compound’s CAS No. 1020253-05-7 is a critical identifier for regulatory and safety documentation. Laboratories handling this material prioritize analytical purity and stability testing, as impurities can significantly impact experimental outcomes. Advanced techniques like HPLC and NMR spectroscopy are employed to verify its quality, addressing common queries about compound characterization in peer-reviewed studies.

From a commercial perspective, 4-Bromo-N-butyl-3-(trifluoromethyl)benzenesulfonamide is supplied by specialized chemical manufacturers catering to R&D sectors. Its pricing and availability are influenced by factors such as raw material costs and synthetic complexity, topics often explored in market analysis reports. Additionally, its inclusion in high-throughput screening libraries underscores its relevance in drug discovery pipelines, a hot topic in biotech innovation forums.

Future research directions for CAS No. 1020253-05-7 may focus on its structure-activity relationships (SAR) to optimize pharmacological profiles. As computational chemistry tools like molecular docking gain traction, this compound could serve as a model for in silico studies predicting binding affinities—a frequently searched topic among medicinal chemists. Its versatility ensures continued interest across multidisciplinary fields, from material science to bioconjugation techniques.

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