• 1. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
  Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
• 2. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 3. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 4. Evolution of important glucosinolates in three common Brassica vegetables during their processing into vegetable powder and in vitro gastric digestion
  Nan Fu,Naphaporn Chiewchan,Xiao Dong Chen Food Funct., 2020,11, 211-220
• 5. Emergence of microfluidic wearable technologies
  Joo Chuan Yeo,Kenry Lab Chip, 2016,16, 4082-4090

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Phenol ethers
• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers

Comprehensive Overview of (2-ethoxyphenyl)methylhydrazine (CAS No. 1016765-83-5): Properties, Applications, and Research Insights

The compound (2-ethoxyphenyl)methylhydrazine (CAS No. 1016765-83-5) is a specialized organic molecule that has garnered significant attention in pharmaceutical and agrochemical research. Its unique structure, featuring a hydrazine moiety linked to a 2-ethoxyphenyl group, makes it a versatile intermediate for synthesizing bioactive molecules. Researchers and industry professionals frequently search for terms like "(2-ethoxyphenyl)methylhydrazine synthesis", "CAS 1016765-83-5 applications", and "hydrazine derivatives in drug discovery", reflecting its relevance in modern chemistry.

One of the key reasons for the growing interest in (2-ethoxyphenyl)methylhydrazine is its potential role in developing novel therapeutics. Recent studies highlight its utility as a building block for heterocyclic compounds, which are pivotal in designing drugs targeting neurological and metabolic disorders. The compound’s ethoxy-phenyl group enhances its lipophilicity, improving membrane permeability—a critical factor in drug bioavailability. This aligns with trending searches such as "improving drug bioavailability with hydrazine derivatives" and "phenylhydrazine analogs in medicine".

From a synthetic chemistry perspective, CAS 1016765-83-5 is often explored for its reactivity in condensation reactions and cyclization processes. Its methylhydrazine segment acts as a nucleophile, enabling the formation of pyrazole and indazole scaffolds—structures prevalent in FDA-approved drugs. Laboratories optimizing green chemistry methods also investigate this compound, as evidenced by queries like "sustainable synthesis of hydrazine derivatives" and "eco-friendly arylhydrazine production".

In agrochemical applications, (2-ethoxyphenyl)methylhydrazine serves as a precursor for crop protection agents. Its ability to modulate plant growth hormones has sparked interest in developing next-generation herbicides and pesticides with reduced environmental impact. This connects to popular search trends such as "green agrochemical intermediates" and "phenylhydrazine-based plant growth regulators", underscoring its alignment with sustainable agriculture.

Analytical characterization of 1016765-83-5 typically involves advanced techniques like HPLC-MS and NMR spectroscopy, ensuring high purity for research applications. Quality control protocols for this compound are frequently discussed in forums, with searches like "CAS 1016765-83-5 purity standards" and "analytical methods for hydrazine compounds" reflecting user concerns. Proper storage under inert conditions is essential to maintain stability, a topic often queried as "handling sensitive hydrazine derivatives".

The commercial availability of (2-ethoxyphenyl)methylhydrazine through specialty chemical suppliers has expanded its accessibility. However, researchers emphasize the need for precise documentation, given regulatory scrutiny on hydrazine-containing substances. This has led to increased searches for "safe handling of arylhydrazines" and "regulatory compliance for CAS 1016765-83-5", highlighting the compound’s dual nature as both a valuable tool and a subject of careful oversight.

Future research directions for 1016765-83-5 may explore its enantioselective applications or hybrid molecular designs combining its core with biocompatible polymers. Such innovations could address current limitations in targeted drug delivery, resonating with search queries like "next-gen hydrazine hybrids" and "smart materials using phenylhydrazines". As interdisciplinary studies grow, this compound’s role in bridging organic chemistry and material science will likely expand.

• 85293-10-3([(2-methoxyphenyl)methyl]hydrazine)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)