• 1. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 2. Exchanged ligands on the surface of a giant cluster: [(MoO3)176(H2O)63(CH3OH)17Hn](32 – n)–
  Chem. Commun., 1998, 1501-1502
• 3. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 4. Excellent electrochemical performance of LiFe0.4Mn0.6PO4 microspheres produced using a double carbon coating process?
  Yong Ping Huang,Tao Tao,Zheng Chen,Wei Han,Ying Wu,Chunjiang Kuang,Shaoxiong Zhou,Ying Chen J. Mater. Chem. A, 2014,2, 18831-18837
• 5. Excimer–monomer switch: a reaction-based approach for selective detection of fluoride?
  Qiao Song,Angela Bamesberger,Lingyun Yang,Haley Houtwed,Haishi Cao Analyst, 2014,139, 3588-3592

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Aminobenzenesulfonamides
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonamides Aminobenzenesulfonamides

3-Amino-N-butyl-N-methylbenzene-1-sulfonamide (CAS No. 1016528-39-4): A Comprehensive Overview

3-Amino-N-butyl-N-methylbenzene-1-sulfonamide, identified by the CAS registry number 1016528-39-4, is a compound of significant interest in the fields of organic chemistry and materials science. This compound is characterized by its unique structure, which combines an aromatic benzene ring with a sulfonamide group and an aminoalkyl substituent. The presence of these functional groups imparts versatile chemical properties, making it a valuable molecule for various applications.

The molecular structure of 3-amino-N-butyl-N-methylbenzene-1-sulfonamide consists of a benzene ring substituted at the 1-position with a sulfonamide group (-SO?NH). The amino group (-NH?) is attached at the 3-position of the benzene ring, while the sulfonamide nitrogen is further substituted with a butyl and methyl group. This combination of functional groups provides the molecule with both nucleophilic and electrophilic sites, enabling it to participate in a wide range of chemical reactions. Recent studies have highlighted its potential as a building block in the synthesis of advanced materials, including polymers and pharmaceutical agents.

One of the most notable aspects of this compound is its role in drug discovery. The sulfonamide group is known to exhibit bioisosteric properties, making it a promising candidate for replacing other functional groups in drug molecules without significantly altering their pharmacokinetic profiles. Recent research has explored its use as a scaffold for developing inhibitors of various enzymes, including kinases and proteases. For instance, studies published in 2023 have demonstrated that derivatives of 3-amino-N-butyl-N-methylbenzene-1-sulfonamide can effectively inhibit the activity of certain oncogenic kinases, suggesting potential applications in cancer therapy.

In addition to its pharmaceutical applications, 3-amino-N-butyl-N-methylbenzene-1-sulfonamide has also found utility in materials science. Its ability to form stable covalent bonds makes it an ideal candidate for synthesizing high-performance polymers. Researchers have reported that incorporating this compound into polymer networks can significantly enhance their mechanical properties, such as tensile strength and flexibility. Furthermore, its ability to undergo click chemistry reactions has opened new avenues for constructing stimuli-responsive materials, which can respond to external stimuli like temperature or pH changes.

The synthesis of 3-amino-N-butyl-N-methylbenzene-1-sulfonamide typically involves multi-step processes that require precise control over reaction conditions. A common approach involves the nucleophilic substitution of an appropriate benzene sulfonate precursor with an amine derivative. Recent advancements in catalytic methods have enabled more efficient and selective syntheses, reducing production costs and minimizing environmental impact. These improvements have made the compound more accessible for large-scale applications.

From an environmental perspective, understanding the degradation pathways of 3-amino-N-butyl-N-methylbenzene-1-sulfonamide is crucial for assessing its potential ecological impact. Studies have shown that under aerobic conditions, the compound undergoes microbial degradation via hydrolysis and oxidation mechanisms. However, further research is needed to evaluate its persistence in different environmental compartments and to develop strategies for mitigating any adverse effects.

In conclusion, 3-amino-N-butyl-N-methylbenzene-1-sulfonamide (CAS No. 1016528-39-4) stands out as a versatile compound with diverse applications across multiple disciplines. Its unique chemical structure, combined with recent advancements in synthetic methodologies and material science, positions it as a key player in future innovations. As research continues to uncover new potentials for this compound, it is likely to play an increasingly important role in both academic and industrial settings.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)