• 1. Modular synthesis of polyene side chain analogues of the potent macrolide antibiotic etnangien by a flexible coupling strategy based on hetero-bis-metallated alkenes
  Mario Altendorfer,Aruna Raja,Florenz Sasse,Herbert Irschik,Dirk Menche Org. Biomol. Chem. 2013 11 2116
• 2. The first convergent total synthesis of penarolide sulfate A2, a novel α-glucosidase inhibitor
  Yangguang Gao,Qiuli Shan,Jun Liu,Linlin Wang,Yuguo Du Org. Biomol. Chem. 2014 12 2071

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Fatty Acyls Fatty alcohols
• Solvents and Organic Chemicals Organic Compounds Alcohol/Ether

Non-8-yn-1-ol (CAS No. 10160-28-8): An Overview of Its Properties, Applications, and Recent Research Advances

Non-8-yn-1-ol (CAS No. 10160-28-8) is a versatile organic compound that has gained significant attention in various fields, including synthetic chemistry, materials science, and pharmaceutical research. This alkyne alcohol is characterized by its unique chemical structure, which includes an alkyne functional group and a hydroxyl group. These features make it an ideal candidate for a wide range of applications, from the synthesis of complex organic molecules to the development of novel materials and therapeutic agents.

The chemical formula of Non-8-yn-1-ol is C₉H₁₆O, and it has a molecular weight of approximately 144.22 g/mol. The compound is a colorless liquid with a boiling point of around 157°C at atmospheric pressure. Its solubility in water is limited, but it readily dissolves in organic solvents such as ethanol, acetone, and dichloromethane. These physical properties make it suitable for use in various chemical reactions and processes.

In synthetic chemistry, Non-8-yn-1-ol is often used as a building block for the synthesis of more complex molecules. The presence of the alkyne group allows for efficient coupling reactions with other functional groups, such as halides and boronic acids, through transition-metal-catalyzed cross-coupling reactions. These reactions are crucial in the synthesis of natural products, pharmaceuticals, and advanced materials. For example, recent studies have shown that Non-8-yn-1-ol can be used to synthesize bioactive compounds with potential therapeutic applications in cancer and neurodegenerative diseases.

The hydroxyl group in Non-8-yn-1-ol also plays a significant role in its reactivity and functionality. It can participate in various chemical transformations, such as esterification, etherification, and oxidation reactions. These transformations are essential for the development of new derivatives with tailored properties. For instance, the conversion of the hydroxyl group to an ester or ether can significantly alter the solubility and stability of the resulting compounds, making them more suitable for specific applications.

In materials science, Non-8-yn-1-ol has been explored for its potential in the synthesis of functional polymers and nanomaterials. The alkyne group can be used to introduce clickable functionalities into polymer chains through click chemistry reactions. This approach has been successfully applied to create polymers with unique mechanical properties, such as self-healing capabilities and stimuli-responsive behavior. Additionally, the hydroxyl group can serve as a reactive site for further functionalization, allowing for the creation of multifunctional materials with enhanced performance.

In the pharmaceutical industry, Non-8-yn-1-ol has shown promise as a precursor for the synthesis of drug candidates. Recent research has focused on its use in the development of prodrugs and drug delivery systems. Prodrugs are inactive derivatives that are converted into active drugs within the body through metabolic processes. The alkyne group in Non-8-yn-1-ol can be used to create prodrugs that are more stable and have improved pharmacokinetic properties compared to their parent compounds. Furthermore, the hydroxyl group can be modified to enhance the solubility and bioavailability of these prodrugs.

The use of Non-8-yn-1-ol in drug delivery systems has also been investigated. Nanoparticles functionalized with alkyne groups can be synthesized using Non-8-yn-1-ol, providing a platform for targeted drug delivery. These nanoparticles can be designed to release their cargo under specific conditions, such as changes in pH or temperature, ensuring that the drug reaches its intended site of action with minimal side effects.

Beyond its applications in synthetic chemistry and pharmaceuticals, Non-8-yn-1-ol has also found use in other areas such as analytical chemistry and environmental science. In analytical chemistry, it serves as a reference standard for quantitative analysis and method development. In environmental science, it is used to study the fate and transport of organic pollutants in aquatic systems.

In conclusion, Non-8-ynnnnnnnnnnnnnnnnnnnnnnnnnn* o* l* (CAS No. 10160-* 2* 8* -* -* -* -* -* -* -* -* -* -* * * * * * * * * * * * * * * * * * * * * * * * * * * 0* ) is a multifaceted compound with a wide range of applications across various scientific disciplines. Its unique chemical structure provides opportunities for innovative research and development in synthetic chemistry, materials science, pharmaceuticals, analytical chemistry, and environmental science. As research continues to advance, it is likely that new applications and uses for this versatile compound will be discovered.

• 2774-84-7(10-Undecyn-1-ol)
• 62914-53-8(15-Hexadecyn-1-ol)
• 18202-11-4(12-Tridecyn-1-ol)
• 18202-12-5(13-Tetradecyn-1-ol)
• 18202-13-6(Pentadec-14-yn-1-ol)
• 5390-04-5(pent-4-yn-1-ol)
• 63478-76-2(hept-6-yn-1-ol)
• 928-90-5(Hex-5-yn-1-ol)
• 390-04-5(Benzoic acid,2-(2-fluoro-4-methylbenzoyl)-)
• 18202-10-3(Dodec-11-yn-1-ol)