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  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
• 2. Fe3O4 nanoparticle chains with N-doped carbon coating: magnetotactic bacteria assisted synthesis and high-rate lithium storage?
  Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
• 3. Evidence for the intrinsic nature of band-gap states electrochemically observed on atomically flat TiO2(110) surfaces?
  Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
• 4. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines Piperidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Piperidines

Comprehensive Introduction to 4-HYDROXYPIPERIDINE-2,2,6,6-D4 (CAS No. 1014695-51-2)

4-HYDROXYPIPERIDINE-2,2,6,6-D4, with the CAS registry number 1014695-51-2, is a deuterated derivative of 4-hydroxypiperidine. This compound is widely utilized in pharmaceutical research, metabolic studies, and NMR spectroscopy due to its unique isotopic labeling. The incorporation of deuterium atoms at the 2,2,6,6 positions enhances its utility in tracing molecular pathways and understanding drug metabolism. Researchers favor this compound for its stability and minimal interference in biological systems, making it a valuable tool in modern drug discovery and deuterated compound synthesis.

The growing demand for deuterated chemicals in the pharmaceutical industry has positioned 4-HYDROXYPIPERIDINE-2,2,6,6-D4 as a critical reagent. Its applications extend to the development of isotope-labeled drugs, which are increasingly explored for improved pharmacokinetics and reduced side effects. Recent studies highlight its role in precision medicine, where deuterium incorporation can alter drug metabolism and prolong therapeutic effects. This aligns with current trends in personalized healthcare, a topic gaining traction among researchers and clinicians alike.

From a synthetic chemistry perspective, 4-HYDROXYPIPERIDINE-2,2,6,6-D4 serves as a versatile building block. Its deuterated structure facilitates the synthesis of complex molecules with enhanced isotopic purity, a requirement for advanced NMR spectroscopy and mass spectrometry analyses. The compound's stability under various reaction conditions further underscores its practicality in organic synthesis and medicinal chemistry. As the pharmaceutical industry shifts toward greener practices, the use of deuterated compounds like this one supports efforts to reduce waste and improve reaction efficiency.

In the context of scientific research, 4-HYDROXYPIPERIDINE-2,2,6,6-D4 is often searched alongside terms such as "deuterated piperidine applications" and "isotope-labeled drug development." These queries reflect the compound's relevance in cutting-edge studies. Additionally, its role in metabolic pathway analysis and drug formulation optimization makes it a frequent subject in academic publications. Researchers and manufacturers alike seek high-purity grades of this compound to ensure reproducibility in experiments and industrial-scale production.

The safety profile and handling guidelines for 4-HYDROXYPIPERIDINE-2,2,6,6-D4 are also of significant interest. While it is not classified as hazardous, proper storage conditions—such as protection from moisture and light—are recommended to maintain its integrity. This aligns with broader industry standards for laboratory chemical management, a topic frequently discussed in research safety protocols. As regulatory frameworks evolve, compliance with Good Manufacturing Practices (GMP) for deuterated compounds remains a priority for suppliers and end-users.

Looking ahead, the demand for 4-HYDROXYPIPERIDINE-2,2,6,6-D4 is expected to rise, driven by advancements in deuterium chemistry and drug development. Its applications in proteomics, kinetics studies, and biomarker research further solidify its importance. For those exploring stable isotope labeling or pharmaceutical intermediates, this compound offers a reliable and efficient solution. As the scientific community continues to innovate, 4-HYDROXYPIPERIDINE-2,2,6,6-D4 will undoubtedly remain a cornerstone in research and industrial applications.

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