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Comprehensive Overview of cis-2-tert-Butoxycarbonylamino-cyclooctanecarboxylic Acid (CAS No. 1013980-15-8)

cis-2-tert-Butoxycarbonylamino-cyclooctanecarboxylic Acid (CAS No. 1013980-15-8) is a specialized cyclooctane derivative widely utilized in pharmaceutical research, organic synthesis, and peptide chemistry. This compound features a unique cis-configuration and a tert-butoxycarbonyl (Boc) protecting group, making it invaluable for controlled reactions in drug discovery. Its molecular structure combines an eight-membered ring with carboxyl and Boc-protected amino functionalities, offering versatility in stereoselective transformations.

In recent years, the demand for Boc-protected amino acids like this compound has surged due to their role in peptide-based therapeutics, a hot topic in biopharmaceutical innovation. Researchers frequently search for "Boc-cyclooctane derivatives" or "CAS 1013980-15-8 applications" to explore its potential in targeted drug delivery and enzyme inhibition studies. The compound’s stability under acidic conditions—owing to the Boc group—makes it ideal for solid-phase peptide synthesis (SPPS), a technique dominating modern peptide production.

The synthesis of cis-2-tert-Butoxycarbonylamino-cyclooctanecarboxylic Acid involves multi-step organic reactions, including cyclooctane ring functionalization and Boc protection. Its chiral center at the 2-position is critical for producing enantiomerically pure intermediates, a key focus area for developers of small-molecule drugs. Analytical techniques like HPLC and NMR are essential for verifying its purity, as impurities could affect downstream applications in bioconjugation or prodrug design.

From an industrial perspective, this compound aligns with the growing interest in sustainable chemistry. Optimized synthetic routes reduce waste, addressing the "green chemistry" queries prevalent in scientific forums. Additionally, its compatibility with automated synthesis platforms caters to the trend of high-throughput screening in drug development. Laboratories often seek "CAS 1013980-15-8 suppliers" or "Boc-cyclooctane carboxylate price" to source high-purity batches for kinase inhibitor research or GPCR-targeted projects.

Beyond pharmaceuticals, cis-2-tert-Butoxycarbonylamino-cyclooctanecarboxylic Acid finds niche applications in material science, particularly in designing bioactive coatings and polymeric carriers. Its amphiphilic properties enable the creation of self-assembling nanostructures, a trending topic in nanotechnology searches. The compound’s logP value and solubility profile are frequently analyzed to predict its behavior in lipid bilayer interactions, a concern for drug permeability studies.

Regulatory compliance is another critical aspect. While not classified as hazardous, proper storage at 2–8°C is recommended to maintain stability. Safety data sheets (SDS) emphasize handling precautions, reflecting the broader industry focus on "lab chemical safety"—a top-searched term among researchers. The compound’s non-hygroscopic nature simplifies storage, unlike many peptide precursors requiring desiccants.

In summary, cis-2-tert-Butoxycarbonylamino-cyclooctanecarboxylic Acid (CAS No. 1013980-15-8) bridges multiple scientific disciplines, from medicinal chemistry to nanomaterials engineering. Its adaptability to Boc-deprotection protocols and compatibility with cross-coupling reactions ensure its relevance in cutting-edge research, answering the frequent query: "How to use Boc-protected cyclooctane acids in catalysis?" As the pharmaceutical industry shifts toward precision medicine, such tailored building blocks will remain indispensable.

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