• 1. Dissolution of cork biopolymers in biocompatible ionic liquids
  Helga Garcia,Rui Ferreira,Marija Petkovic,Jamie L. Ferguson,Maria C. Leit?o,H. Q. Nimal Gunaratne,Luís Paulo N. Rebelo Green Chem., 2010,12, 367-369
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• 3. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
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• Solvents and Organic Chemicals Organic Compounds Phenylpropanoids and polyketides Cinnamic acids and derivatives Cinnamic acids
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Overview of 2-Cyano-3-phenylprop-2-enoic Acid (CAS No. 1011-92-3): Properties, Applications, and Innovations

2-Cyano-3-phenylprop-2-enoic Acid (CAS No. 1011-92-3), also known as α-Cyano-β-phenylacrylic acid, is a versatile organic compound with a wide range of applications in pharmaceuticals, agrochemicals, and material science. This cyanoacrylate derivative is characterized by its unique molecular structure, featuring a cyano group and a phenyl ring, which contribute to its reactivity and functional diversity. In recent years, this compound has garnered significant attention due to its potential in drug discovery, organic synthesis, and green chemistry initiatives.

The growing interest in sustainable chemical processes has positioned 2-Cyano-3-phenylprop-2-enoic Acid as a key intermediate in the development of eco-friendly methodologies. Researchers are exploring its role in catalysis and biodegradable materials, aligning with global trends toward reducing environmental impact. Additionally, its pharmacological properties have been investigated for potential applications in anti-inflammatory and antimicrobial agents, making it a subject of interest in medicinal chemistry.

From a structural perspective, the presence of both electron-withdrawing (cyano) and electron-donating (phenyl) groups in 2-Cyano-3-phenylprop-2-enoic Acid enables diverse chemical transformations. This duality facilitates its use in Michael additions, cycloadditions, and other name reactions, which are critical for constructing complex molecules. Its melting point, solubility, and stability under various conditions further enhance its utility in industrial and laboratory settings.

In the context of user-searched queries, common questions include: "What are the synthetic routes for 2-Cyano-3-phenylprop-2-enoic Acid?" and "How is this compound used in peptide coupling reactions?". Addressing these, the compound is typically synthesized via Knoevenagel condensation between phenylacetaldehyde and cyanoacetic acid, a method praised for its high yield and mild reaction conditions. Its role in peptide synthesis stems from its ability to act as a protecting group or coupling agent, streamlining the production of bioactive peptides.

Another trending topic is the integration of 2-Cyano-3-phenylprop-2-enoic Acid into nanotechnology and smart materials. Recent studies highlight its potential in conductive polymers and sensors, where its π-conjugated system enhances electron transfer. This aligns with the surge in demand for wearable electronics and energy storage solutions, further expanding its market relevance.

Quality control and analytical methods for CAS No. 1011-92-3 are also frequently discussed. Techniques such as HPLC, NMR, and mass spectrometry are employed to ensure purity and consistency, particularly for pharmaceutical-grade batches. Regulatory compliance, including REACH and GMP standards, underscores the compound's safe handling and commercialization.

In summary, 2-Cyano-3-phenylprop-2-enoic Acid (CAS No. 1011-92-3) is a multifaceted compound bridging traditional chemistry and cutting-edge innovations. Its applications span from life sciences to advanced materials, driven by its adaptable chemistry and alignment with sustainability goals. As research progresses, its role in addressing global challenges like drug resistance and renewable energy is expected to grow, solidifying its importance in modern science.

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