Cas no 1011-65-0 (Methyl indole-5-carboxylate)
Methyl indole-5-carboxylate Chemical and Physical Properties
Names and Identifiers
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- Methyl indole-5-carboxylate
- Indole-5-carboxylic acid methyl ester
- Methyl 1H-indole-5-carboxylate
- 1H-Indole-5-carboxylic acid, methyl ester
- Methyl Indole-6-carb
- Methyl Indole-6-carboxylate
- 5-Indolecarboxylic acid methyl ester
- M2325G1
- RARECHEM AH BS 0114
- 5-(Methoxycarbonyl)indole
- METHYL INDOLE-5-CABOXYLATE
- Methyl indole-5-carboxyla...
- 5-(Methoxycarbonyl)-1H-indole
- Methyl 1H-indol-5-carboxylate
- Indole-5-carboxylic acid, methyl ester
- LABOTEST-BB LT00454878
- INDOLE-5-CARBOXYLIC ACID METHYL ESTER(I5CAMe)
- Methyl indole-5-carboxylate,99%
- H-Indole-5-carboxylic Acid Methyl Ester
- Methyl indole-5-carboxylate in stock Factory
- 1H-Indole-5-carboxylic acid methyl ester
- 5-methoxycarbonylindole
- methylindole-5-carboxylate
- methyl 5-indolecarboxylate
- EN300-154351
- methyl 5-indole-carboxylate
- HMS3330O22
- I0545
- Z1153206326
- A800341
- SS-6027
- PB29029
- DRYBMFJLYYEOBZ-UHFFFAOYSA-N
- MFCD00153023
- SCHEMBL103794
- Indole-5-carboxylate
- 5-methloxycarbonylindole
- BCP27016
- HMS2220E16
- Methyl indole-5-carboxylate, 99%
- methyl-5-indole carboxylate
- DTXSID00372193
- CHEBI:194927
- MLS001250153
- AM81120
- SB10354
- 5-Methoxycarbonyl-1H-indole
- InChI=1/C10H9NO2/c1-13-10(12)8-2-3-9-7(6-8)4-5-11-9/h2-6,11H,1H
- Methyl-indole-5-carboxylate
- SMR000686020
- SY003617
- CS-D1099
- AKOS000265192
- 1011-65-0
- BB 0253734
- A16257
- Indole-5-carboxylic acid methyl ester, 98%
- 5-(methloxycarbonyl)indole
- SY282727
- I-2515
- 5-Indolecarboxylicacidmethylester
- FT-0620502
- methyl 5-indole carboxylate
- AC-3031
- BDBM93019
- ISUPSL100238
- CHEMBL109238
-
- MDL： MFCD00153023
- Inchi： 1S/C10H9NO2/c1-13-10(12)8-2-3-9-7(6-8)4-5-11-9/h2-6,11H,1H3
- InChI Key： DRYBMFJLYYEOBZ-UHFFFAOYSA-N
- SMILES： O(C)C(C1C=CC2=C(C=CN2)C=1)=O
- BRN： 474256
Computed Properties
- Exact Mass: 175.06300
- Monoisotopic Mass: 175.063
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 13
- Rotatable Bond Count: 2
- Complexity: 205
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Surface Charge: 0
- Tautomer Count: 3
- XLogP3: nothing
- Topological Polar Surface Area: 42.1A^2
Experimental Properties
- Color/Form: Off white powder.
- Density: 1.253
- Melting Point: 125.0 to 129.0 deg-C
- Boiling Point: 331.7 °C at 760 mmHg
- Flash Point: 154.4℃
- Refractive Index: 1.639
- Solubility: soluble in Chloroform, Methanol
- Water Partition Coefficient: Insoluble in water.
- PSA: 42.09000
- LogP: 1.95450
- Solubility: Not determined
- pka: 16.09±0.30(Predicted)
Methyl indole-5-carboxylate Security Information
-
Symbol:
- Prompt：warning
- Signal Word：Warning
- Hazard Statement： H315-H319
- Warning Statement： P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
- Hazardous Material transportation number：NONH for all modes of transport
- WGK Germany：3
- Hazard Category Code： 36/37/38
- Safety Instruction： S26-S36
-
Hazardous Material Identification：
- Safety Term：S26;S36
- Risk Phrases：R36/37/38
- HazardClass：IRRITANT
- Storage Condition：Store at room temperature
Methyl indole-5-carboxylate Customs Data
- HS CODE：2933990090
- Customs Data：
China Customs Code:
2933990090Overview:
2933990090. Other heterocyclic compounds containing only nitrogen heteroatoms. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Methyl indole-5-carboxylate Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| Fluorochem | 016239-1g |
Methyl indole-5-carboxylate |
1011-65-0 | 98% | 1g |
￡12.00 | 2022-03-01 | |
| Fluorochem | 016239-5g |
Methyl indole-5-carboxylate |
1011-65-0 | 98% | 5g |
￡23.00 | 2022-03-01 | |
| Fluorochem | 016239-10g |
Methyl indole-5-carboxylate |
1011-65-0 | 98% | 10g |
￡41.00 | 2022-03-01 | |
| Fluorochem | 016239-25g |
Methyl indole-5-carboxylate |
1011-65-0 | 98% | 25g |
￡94.00 | 2022-03-01 | |
| Fluorochem | 016239-100g |
Methyl indole-5-carboxylate |
1011-65-0 | 98% | 100g |
￡328.00 | 2022-03-01 | |
| Alichem | A199000343-25g |
Methyl indole-5-carboxylate |
1011-65-0 | 98% | 25g |
$154.15 | 2023-09-04 | |
| Chemenu | CM105152-25g |
methyl 1H-indole-5-carboxylate |
1011-65-0 | 95%+ | 25g |
$122 | 2021-08-06 | |
| Chemenu | CM105152-100g |
methyl 1H-indole-5-carboxylate |
1011-65-0 | 95%+ | 100g |
$295 | 2021-08-06 | |
| TRC | M313485-1g |
Methyl Indole-5-carboxylate |
1011-65-0 | 1g |
$ 52.00 | 2023-09-07 | ||
| TRC | M313485-5g |
Methyl Indole-5-carboxylate |
1011-65-0 | 5g |
$ 126.00 | 2023-09-07 |
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Methyl indole-5-carboxylate Related Literature
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Kai-Li Tan,Hao-Nan Wang,Tao Dong,Cheng-Pan Zhang Org. Biomol. Chem. 2021 19 5368
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Rameshwar Prasad Pandit,Jae-Jin Shim,Sung Hong Kim,Yong Rok Lee RSC Adv. 2017 7 55288
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Ping Wang,Baozhong Zhang RSC Adv. 2021 11 16480
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Mirim Kim,Jihye Park,Satyasheel Sharma,Sangil Han,Sang Hoon Han,Jong Hwan Kwak,Young Hoon Jung,In Su Kim Org. Biomol. Chem. 2013 11 7427
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Mirim Kim,Jihye Park,Satyasheel Sharma,Sangil Han,Sang Hoon Han,Jong Hwan Kwak,Young Hoon Jung,In Su Kim Org. Biomol. Chem. 2013 11 7427
Additional information on Methyl indole-5-carboxylate
Recent Advances in Methyl Indole-5-carboxylate (CAS: 1011-65-0) Research: A Comprehensive Review
Methyl indole-5-carboxylate (CAS: 1011-65-0) is a key intermediate in the synthesis of various biologically active compounds, particularly in the fields of medicinal chemistry and drug discovery. Recent studies have highlighted its significance as a building block for the development of novel therapeutic agents targeting a range of diseases, including cancer, neurological disorders, and infectious diseases. This research briefing provides an overview of the latest advancements related to this compound, focusing on its synthetic applications, biological activities, and potential clinical implications.
One of the most notable developments in the past year involves the use of Methyl indole-5-carboxylate as a precursor in the synthesis of indole-based kinase inhibitors. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibit potent inhibitory activity against cyclin-dependent kinases (CDKs), which are critical targets in cancer therapy. The researchers utilized a structure-activity relationship (SAR) approach to optimize the compound's efficacy, achieving nanomolar IC50 values in vitro. These findings underscore the potential of Methyl indole-5-carboxylate as a versatile scaffold for anticancer drug development.
In addition to its applications in oncology, Methyl indole-5-carboxylate has shown promise in the field of neuropharmacology. A recent study in ACS Chemical Neuroscience reported that certain analogs of this compound act as selective serotonin receptor modulators, with potential applications in treating depression and anxiety disorders. The study employed molecular docking simulations and in vivo behavioral assays to validate the compound's mechanism of action, revealing significant anxiolytic effects in animal models without the side effects commonly associated with current treatments.
From a synthetic chemistry perspective, innovative methodologies for the efficient production of Methyl indole-5-carboxylate have been developed. A 2024 paper in Organic Process Research & Development described a novel catalytic system that improves the yield and purity of this compound while reducing environmental impact. The green chemistry approach employed in this study aligns with the growing emphasis on sustainable pharmaceutical manufacturing practices.
Looking forward, the versatility of Methyl indole-5-carboxylate continues to inspire new research directions. Current clinical trials are investigating its derivatives as potential treatments for rare genetic disorders, while computational studies are exploring its utility in drug repurposing efforts. As the scientific community gains deeper understanding of this compound's pharmacological properties, its role in advancing precision medicine is becoming increasingly apparent.
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