Cas no 1009335-36-7 ((3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol;hydrochloride)

(3R,5R)-5-(Hydroxymethyl)pyrrolidin-3-ol hydrochloride is a chiral pyrrolidine derivative characterized by its stereospecific hydroxyl and hydroxymethyl functional groups. This compound serves as a valuable intermediate in organic synthesis, particularly in the development of pharmaceuticals and bioactive molecules. Its rigid pyrrolidine backbone and polar substituents enhance its utility in asymmetric synthesis and as a building block for complex molecular architectures. The hydrochloride salt form improves solubility and stability, facilitating handling and storage. The defined stereochemistry at the 3R and 5R positions ensures consistency in chiral applications, making it a preferred choice for researchers requiring high enantiomeric purity. Its versatility supports applications in medicinal chemistry and catalyst design.
(3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol;hydrochloride structure
1009335-36-7 structure
Product Name:(3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol;hydrochloride
CAS No:1009335-36-7
MF:C5H13ClNO2
MW:154.6152
MDL:MFCD17676315
CID:2086159
PubChem ID:67455093
Update Time:2025-06-09

(3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol;hydrochloride Chemical and Physical Properties

Names and Identifiers

    • (2R,4R)-4-Hydroxy-2-pyrrolidinemethanol Hydrochloride
    • (3R,5R)-5-(Hydroxymethyl)pyrrolidin-3-ol hydrochloride
    • (3R,5R)-5-(HYDROXYMETHYL)PYRROLIDIN-3-OL HCL
    • 4-HYDROXY-(2R,4R)-2-PYRROLIDINEMETHANOLHYDROCHLORIDE
    • [(2R,4R)-4-Hydroxypyrrolidin-1-ium-2-yl]methyloxidanium;chloride
    • (3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol;hydrochloride
    • (3R,5R)-5-(Hydroxymethyl)pyrrolidine-3-ol HCl
    • IUHDMWJWUWKOFE-TYSVMGFPSA-N
    • DS-19068
    • CS-0181811
    • 2-Pyrrolidinemethanol, 4-hydroxy-, hydrochloride (1:1), (2R,4R)-
    • MFCD17676315
    • SCHEMBL2567829
    • 1009335-36-7
    • (3R,5R)-5-(hydroxymethyl)pyrrolidin-3-olhydrochloride
    • AKOS027446398
    • DB-102200
    • MDL: MFCD17676315
    • Inchi: 1S/C5H11NO2.ClH/c7-3-4-1-5(8)2-6-4;/h4-8H,1-3H2;1H/p+1/t4-,5-;/m1./s1
    • InChI Key: IUHDMWJWUWKOFE-TYSVMGFPSA-O
    • SMILES: [Cl-].O([H])[C@@]1([H])C([H])([H])[N+]([H])([H])[C@@]([H])(C([H])([H])[O+]([H])[H])C1([H])[H]

Computed Properties

  • Exact Mass: 153.0556563g/mol
  • Monoisotopic Mass: 153.0556563g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 2
  • Heavy Atom Count: 9
  • Rotatable Bond Count: 1
  • Complexity: 76.8
  • Covalently-Bonded Unit Count: 2
  • Defined Atom Stereocenter Count: 2
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Topological Polar Surface Area: 37.8

(3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol;hydrochloride Security Information

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Additional information on (3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol;hydrochloride

Compound CAS No. 1009335-36-7: (3R,5R)-5-(Hydroxymethyl)pyrrolidin-3-ol; Hydrochloride

The compound with CAS No. 1009335-36-7, commonly referred to as (3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol; hydrochloride, is a biologically active molecule that has garnered significant attention in the fields of organic chemistry and pharmacology. This compound belongs to the class of pyrrolidine derivatives, which are known for their diverse applications in drug discovery and development. The (3R,5R) stereochemistry plays a crucial role in determining its physical and chemical properties, as well as its biological activity.

Recent studies have highlighted the potential of (3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol; hydrochloride in modulating cellular signaling pathways. Researchers have demonstrated that this compound exhibits selective binding to specific receptors, making it a promising candidate for therapeutic interventions in various diseases. For instance, its ability to inhibit certain kinases has been explored in the context of cancer treatment, where targeted therapies are highly sought after.

The synthesis of (3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol; hydrochloride involves a multi-step process that requires precise control over stereochemistry. The use of chiral catalysts and enantioselective reactions has enabled the efficient production of this compound with high optical purity. This is particularly important for its application in drug development, where stereochemistry can significantly influence pharmacokinetics and efficacy.

In terms of physical properties, (3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol; hydrochloride is characterized by its melting point and solubility profiles. These properties are critical for determining its suitability in various dosage forms, such as tablets or injections. Recent advancements in analytical techniques have allowed for more accurate characterization of this compound, ensuring its quality and consistency for pharmaceutical applications.

The biological activity of (3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol; hydrochloride has been extensively studied using in vitro and in vivo models. Preclinical data suggest that it exhibits potent anti-inflammatory and antioxidant effects, which could be beneficial in treating chronic diseases such as neurodegenerative disorders. Furthermore, its ability to cross the blood-brain barrier has been a focal point of recent research, highlighting its potential for central nervous system-related therapies.

From a regulatory standpoint, the development of (3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol; hydrochloride as a pharmaceutical agent requires stringent compliance with international standards. Regulatory agencies emphasize the importance of thorough toxicological evaluations and bioavailability studies to ensure patient safety and efficacy. Recent regulatory updates have also emphasized the need for sustainable manufacturing practices to minimize environmental impact.

In conclusion, (3R,5R)-5-(hydroxymethyl)pyrrolidin-3-ol; hydrochloride represents a significant advancement in the field of medicinal chemistry. Its unique chemical structure and biological activity make it a valuable tool for addressing unmet medical needs. As research continues to uncover new insights into its mechanisms of action and therapeutic potential, this compound is poised to play a pivotal role in the development of innovative treatments across various therapeutic areas.

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