• 1. Aggregation-induced emission of luminol: a novel strategy for fluorescence ratiometric detection of ALP and As(v) with high sensitivity and selectivity?
  Yuan-Jun Tong,Lu-Dan Yu,Lu-Lu Wu,Shu-Ping Cao,Ru-Ping Liang,Li Zhang,Xing-Hua Xia,Jian-Ding Qiu Chem. Commun., 2018,54, 7487-7490
• 2. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 3. Aggregation of the metallocycles {Cu8} and {Cu20} using [Cu(bp)] units (H2bp = bis(2-hydroxybenzyl)amine): structures and magnetic properties?
  Mei-Yu Xu,Ya-Ting Wang,Qing-Ling Ni,Zi-Hao Zhang,Guang-Ming Liang,Liu-Cheng Gui Dalton Trans., 2016,45, 4993-4997
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Halobenzenes Iodobenzenes
• Other Chemical Reagents Derivatization Reagents
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Comprehensive Overview of 2-Iodophenylboronic Acid (CAS No. 1008106-86-2): Properties, Applications, and Industry Insights

2-Iodophenylboronic acid (CAS No. 1008106-86-2) is a versatile boronic acid derivative widely utilized in organic synthesis, pharmaceutical research, and material science. This compound, characterized by its iodine-substituted phenyl ring and boronic acid functional group, plays a pivotal role in Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern drug discovery and agrochemical development. Its unique structural features enable the formation of carbon-carbon bonds, making it indispensable for constructing complex molecular architectures.

The growing demand for 2-Iodophenylboronic acid is driven by its applications in bioconjugation, proteomics, and the development of PET imaging agents. Researchers frequently search for "2-Iodophenylboronic acid solubility," "CAS 1008106-86-2 suppliers," and "Suzuki coupling with iodophenylboronic acid," reflecting its relevance in both academic and industrial settings. Recent advancements in green chemistry have also spotlighted this compound’s potential in catalyst-free reactions and sustainable synthesis methodologies.

From a technical perspective, 2-Iodophenylboronic acid exhibits moderate stability under inert atmospheres but requires storage at low temperatures to prevent protodeboronation. Its melting point (typically 150–160°C) and NMR spectral data (e.g., δ¹¹B ~30 ppm) are critical for quality control. Analytical techniques like HPLC and mass spectrometry are commonly employed to verify purity, especially for pharmaceutical-grade batches.

In the context of drug development, this compound serves as a key intermediate for tyrosine kinase inhibitors and anticancer agents. Searches for "2-Iodophenylboronic acid in medicinal chemistry" or "CAS 1008106-86-2 patent applications" highlight its commercial significance. Notably, its iodine moiety facilitates further functionalization via halogen exchange reactions, expanding its utility in high-throughput screening libraries.

Emerging trends in nanotechnology have further broadened the scope of 2-Iodophenylboronic acid, particularly in designing boron-doped graphene for energy storage devices. Discussions around "boronic acid MOFs" (metal-organic frameworks) and "bioimaging probes" underscore its interdisciplinary appeal. Regulatory compliance, such as REACH certification for CAS No. 1008106-86-2, remains a priority for global suppliers to ensure safe handling and transport.

To address common queries like "How to purify 2-Iodophenylboronic acid?" or "Alternative catalysts for Suzuki reactions," experts recommend recrystallization from ethanol/water mixtures and palladium nanoparticle systems, respectively. The compound’s MSDS (Material Safety Data Sheet) emphasizes standard lab precautions, though it is not classified as hazardous under normal usage.

In summary, 2-Iodophenylboronic acid (CAS No. 1008106-86-2) bridges fundamental research and industrial innovation, with its demand fueled by breakthroughs in precision medicine and renewable materials. Its synergy with AI-driven molecular design tools and automated synthesis platforms positions it as a critical enabler of future scientific advancements.

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