Cas no 1008-65-7 (2-(1,3,4-Oxadiazol-2-yl)phenol)

2-(1,3,4-Oxadiazol-2-yl)phenol is a heterocyclic compound featuring a phenol group linked to a 1,3,4-oxadiazole ring. This structure imparts unique electronic and steric properties, making it valuable in pharmaceutical and materials chemistry. The oxadiazole moiety enhances stability and offers potential for hydrogen bonding and π-π interactions, while the phenolic hydroxyl group provides reactivity for further functionalization. Its applications include use as a building block in drug discovery, particularly for antimicrobial and anti-inflammatory agents, as well as in the development of organic electronic materials due to its conjugated system. The compound's balanced lipophilicity and polarity also contribute to its utility in medicinal chemistry.
2-(1,3,4-Oxadiazol-2-yl)phenol structure
1008-65-7 structure
Product Name:2-(1,3,4-Oxadiazol-2-yl)phenol
CAS No:1008-65-7
MF:C8H6N2O2
MW:162.145441532135
MDL:MFCD00020713
CID:83301
PubChem ID:13883
Update Time:2025-06-30

2-(1,3,4-Oxadiazol-2-yl)phenol Chemical and Physical Properties

Names and Identifiers

    • 2-(1,3,4-Oxadiazol-2-yl)phenol
    • 2-(o-Hydroxyphenyl)-1,3,4-oxadiazole
    • Eudormil
    • Hypnazol
    • Viodor
    • 2-(1,3,4-Oxadiazol-2-yl)benzenol
    • JL-512
    • fenadiazole
    • Phenadiazole
    • 2-(1,3,4-oxadiazol-2-yl)-pheno
    • AKOS BBS-00004547
    • Fenadiazole [INN:DCF]
    • IFLab2_000252
    • AKOS000269733
    • 8YX6HIZ0IP
    • SDCCGMLS-0065586.P001
    • 10A-002
    • NS00126328
    • MFCD00020713
    • FT-0608353
    • IFLab1_006238
    • CHEMBL1903897
    • Q5442960
    • JL 512
    • o-1,3,4-Oxodiazol-2-ylphenol
    • Fenadiazolum [INN-Latin]
    • MLS002703546
    • PHENOL, 2-(1,3,4-OXADIAZOL-2-YL)-
    • BRD-K18362446-001-06-8
    • Z57438332
    • BAA00865
    • 2-(o-Hydroxyphenyl)-1,4-oxadiazole
    • J. L. 512
    • FENADIAZOLE [MI]
    • 2-(1,4-Oxadiazol-2-yl)phenol
    • 1,3,4-Oxadiazole, 2-(o-hydroxyphenyl)-
    • NSC-100729
    • 1008-65-7
    • DTXSID7057608
    • 4-27-00-07344 (Beilstein Handbook Reference)
    • Tox21_113759
    • 2-(2-hydroxyphenyl)-1,3,4-oxadiazole
    • NCGC00253631-01
    • SMR001570263
    • AT-057/42646623
    • HMS1429L12
    • EN300-110858
    • 1,4-Oxadiazole, 2-(o-hydroxyphenyl)-
    • o-1,4-Oxadiazol-2-ylphenol
    • A853757
    • CS-0034608
    • HY-115139
    • ortho-1,3,4-Oxadiazol-2-yl-phenol
    • FENADIAZOLE [INN]
    • J-505292
    • Fenadiazolum
    • BRN 0136925
    • Phenol,3,4-oxadiazol-2-yl-
    • IDI1_019278
    • CAS-1008-65-7
    • DTXCID5031397
    • Phenol, o-1,3,4-oxadiazol-2-yl-
    • Phenol,3,4-oxadiazol-2-yl)-
    • 2-(1,3,4-Oxadiazol-2-yl)-phenol
    • CHEBI:134791
    • o-1,3,4-Oxadiazol-2-ylphenol
    • SCHEMBL555484
    • Fenadiazol [INN-Spanish]
    • UNII-8YX6HIZ0IP
    • NSC100729
    • NSC 100729
    • Fenadiazol
    • Fenadiazol (INN-Spanish)
    • Fenadiazolum (INN-Latin)
    • DB-058510
    • Phenol, o-1,3,4-oxadiazol-2-yl-(8CI)
    • STK409833
    • MDL: MFCD00020713
    • Inchi: 1S/C8H6N2O2/c11-7-4-2-1-3-6(7)8-10-9-5-12-8/h1-5,11H
    • InChI Key: OINXXHYENYVYPB-UHFFFAOYSA-N
    • SMILES: O1C=NN=C1C1C=CC=CC=1O

Computed Properties

  • Exact Mass: 162.04300
  • Monoisotopic Mass: 162.043
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 12
  • Rotatable Bond Count: 1
  • Complexity: 337
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 1
  • Surface Charge: 0
  • Tautomer Count: 3
  • XLogP3: 1.3
  • Topological Polar Surface Area: 50.7

Experimental Properties

  • Color/Form: Not determined
  • Density: 1.38
  • Melting Point: 100 °C
  • Boiling Point: bp0.1 180°
  • Flash Point: 115.3°C
  • Refractive Index: 1.646
  • PSA: 59.15000
  • LogP: 1.44220
  • Solubility: Not determined

2-(1,3,4-Oxadiazol-2-yl)phenol Security Information

  • Safety Instruction: S26-S37/39
  • RTECS:SM5850000
  • Hazardous Material Identification: Xi
  • HazardClass:IRRITANT
  • Risk Phrases:R36/37/38
  • Safety Term:S26;S37/39

2-(1,3,4-Oxadiazol-2-yl)phenol Customs Data

  • HS CODE:2934999090
  • Customs Data:

    China Customs Code:

    2934999090

    Overview:

    2934999090. Other heterocyclic compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

2-(1,3,4-Oxadiazol-2-yl)phenol Pricemore >>

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2-(1,3,4-Oxadiazol-2-yl)phenol Suppliers

Amadis Chemical Company Limited
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(CAS:1008-65-7)2-(1,3,4-Oxadiazol-2-yl)phenol
Order Number:A853757
Stock Status:in Stock
Quantity:25g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 07:46
Price ($):1011.0

2-(1,3,4-Oxadiazol-2-yl)phenol Related Literature

Additional information on 2-(1,3,4-Oxadiazol-2-yl)phenol

Professional Introduction to Compound with CAS No. 1008-65-7 and Product Name: 2-(1,3,4-Oxadiazol-2-yl)phenol

Compound with the CAS number 1008-65-7 and the product name 2-(1,3,4-Oxadiazol-2-yl)phenol represents a significant area of interest in the field of chemical biology and pharmaceutical research. This compound, characterized by its unique structural framework, has garnered attention due to its potential applications in various therapeutic domains. The molecular structure of 2-(1,3,4-Oxadiazol-2-yl)phenol incorporates a phenolic moiety linked to a 1,3,4-oxadiazole ring, which is a heterocyclic compound known for its diverse pharmacological properties.

The 1,3,4-Oxadiazole ring is a key pharmacophore in medicinal chemistry, contributing to the compound's biological activity through its ability to interact with multiple targets in biological systems. This heterocycle is widely recognized for its role in the development of antimicrobial, antiviral, and anti-inflammatory agents. The presence of the phenol group in 2-(1,3,4-Oxadiazol-2-yl)phenol further enhances its potential as a bioactive molecule by providing a site for hydrogen bonding and other non-covalent interactions with biological targets.

Recent advancements in the field of drug discovery have highlighted the importance of 1,3,4-Oxadiazole derivatives in addressing unmet medical needs. Studies have demonstrated that compounds incorporating this scaffold exhibit promising activities against various diseases, including cancer and infectious disorders. The structural flexibility of the 1,3,4-Oxadiazole ring allows for modifications that can fine-tune its biological activity, making it an attractive scaffold for medicinal chemists.

The compound with CAS No. 1008-65-7, specifically named as 2-(1,3,4-Oxadiazol-2-yl)phenol, has been investigated for its potential pharmacological effects. Research indicates that this molecule may possess antioxidant properties due to the presence of the phenolic group. Antioxidants are crucial in mitigating oxidative stress, which is implicated in numerous pathological conditions such as neurodegenerative diseases and cardiovascular disorders. The oxadiazole moiety also contributes to the compound's stability and bioavailability, factors that are essential for effective drug development.

In vitro studies have shown that 2-(1,3,4-Oxadiazol-2-yl)phenol exhibits inhibitory effects on certain enzymes and receptors relevant to inflammation and cell proliferation. These findings suggest that the compound could be a valuable candidate for further exploration in therapeutic applications. The ability of this molecule to modulate biological pathways makes it a promising lead for drug discovery efforts aimed at developing novel treatments.

The synthesis of 2-(1,3,4-Oxadiazol-2-yl)phenol involves multi-step organic reactions that require careful optimization to ensure high yield and purity. Advanced synthetic methodologies have been employed to enhance the efficiency of these processes. Techniques such as transition metal-catalyzed cross-coupling reactions have been utilized to construct the complex framework of the molecule in a streamlined manner. These synthetic approaches not only improve the accessibility of the compound but also allow for modifications that can enhance its pharmacological profile.

The chemical properties of CAS No. 1008-65-7, including its solubility and stability under various conditions, are critical factors that influence its suitability for pharmaceutical applications. Solubility is particularly important as it determines the bioavailability of the compound when administered orally or through other routes. Stability studies have been conducted to assess the compound's shelf life and compatibility with different formulations. These studies are essential for ensuring that the compound remains effective and safe throughout its intended use.

Recent research has also explored the potential use of 2-(1,3,4-Oxadiazol-2-yl)phenol in combination therapies. The concept of combination therapy involves using multiple drugs or compounds to achieve synergistic effects that enhance therapeutic outcomes. This approach has been successfully applied in various areas of medicine, including oncology and infectious diseases. By combining 2-(1,3,4-Oxadiazol-2-yl)phenol with other bioactive molecules, researchers aim to develop treatment strategies that are more effective than single-agent therapies.

The development of novel drug candidates often involves rigorous preclinical testing to evaluate their safety and efficacy. Preclinical studies include in vitro assays and animal models that provide valuable insights into the potential therapeutic effects of compounds like CAS No. 1008-65-7. These studies help identify any potential adverse effects and optimize dosing regimens before human trials are initiated.

The future prospects for 2-(1,3,4-Oxadiazol-2-yl)phenol are promising given its unique structural features and demonstrated biological activity. Ongoing research aims to further elucidate its mechanisms of action and explore new therapeutic applications. Collaborative efforts between academic institutions and pharmaceutical companies are essential for advancing this field and bringing new treatments to patients who need them.

In conclusion,CAS No. 1008-65-7, identified as 2-(1,3,4-Oxadiazol -)phenols) represents a significant advancement in chemical biology and pharmaceutical research. Its unique structure, incorporating both phenolicandOxadiazole,moieties offers diverse therapeutic possibilities particularlyin addressing inflammatory disease processes. As research continues,this compound holds great promise as a lead candidate for future drug development,offering hope for improved treatment options across multiple medical conditions.

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Amadis Chemical Company Limited
(CAS:1008-65-7)2-(1,3,4-Oxadiazol-2-yl)phenol
A853757
Purity:99%
Quantity:25g
Price ($):1011.0
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