• 1. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 2. Dissociation of aryl sulfonyl phthalimide radical anions: relevance to the biological activity of arylsulfonyl amides?
  Abdelaziz Houmam,Emad M. Hamed Chem. Commun., 2012,48, 11328-11330
• 3. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991
• 4. Establishing plasmon contribution to chemical reactions: alkoxyamines as a thermal probe?
  Olga Guselnikova,Gérard Audran,Jean-Patrick Joly,Andrii Trelin,Evgeny V. Tretyakov,Vaclav Svorcik,Oleksiy Lyutakov,Sylvain R. A. Marque Chem. Sci., 2021,12, 4154-4161
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  Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Comprehensive Guide to 2-(4-Bromo-3-methyl-1H-pyrazol-1-yl)-2-methylpropanoic acid (CAS No. 1006473-56-8): Properties, Applications, and Market Insights

2-(4-Bromo-3-methyl-1H-pyrazol-1-yl)-2-methylpropanoic acid (CAS 1006473-56-8) is a specialized brominated pyrazole derivative with significant relevance in pharmaceutical and agrochemical research. This compound, often abbreviated as BMPMPA in scientific literature, features a unique molecular structure combining a pyrazole ring with a propanoic acid moiety, making it valuable for drug discovery and material science applications. Researchers frequently search for "CAS 1006473-56-8 supplier" or "BMPMPA synthesis method," reflecting growing interest in this versatile intermediate.

The compound's physicochemical properties include a molecular weight of 276.13 g/mol and a purity standard typically exceeding 97%. Its bromine substitution at the 4-position of the pyrazole ring enhances its reactivity in cross-coupling reactions, particularly useful in palladium-catalyzed transformations. Current market trends show increased demand for halogenated heterocycles like 2-(4-Bromo-3-methyl-1H-pyrazol-1-yl)-2-methylpropanoic acid, driven by their applications in developing kinase inhibitors and crop protection agents.

In medicinal chemistry, this compound serves as a key building block for small molecule therapeutics. Its structural features align with popular search queries such as "pyrazole-based drug candidates 2024" and "brominated pharmaceutical intermediates." The methylpropanoic acid segment contributes to improved water solubility compared to similar bromopyrazole derivatives, addressing a common challenge in drug formulation.

The synthesis of 2-(4-Bromo-3-methyl-1H-pyrazol-1-yl)-2-methylpropanoic acid typically involves multi-step organic reactions starting from commercially available 3-methyl-1H-pyrazole. Process optimization remains an active research area, with recent patents focusing on green chemistry approaches to reduce environmental impact – a topic frequently searched as "sustainable heterocycle synthesis." Analytical characterization via HPLC, NMR, and mass spectrometry confirms the compound's identity and purity.

Beyond pharmaceuticals, CAS 1006473-56-8 finds applications in advanced material science. Its ability to coordinate with metal ions makes it valuable for developing functional polymers and coordination complexes. Industry reports indicate growing interest in "pyrazole-containing smart materials," particularly for electronic devices and sensor technologies.

Storage and handling of 2-(4-Bromo-3-methyl-1H-pyrazol-1-yl)-2-methylpropanoic acid require standard laboratory precautions. The compound demonstrates stability at room temperature when protected from moisture, with recommended storage conditions aligning with searches for "stable bromopyrazole storage." Global suppliers typically offer this chemical in gram to kilogram quantities, catering to both research and development-scale requirements.

Recent scientific publications highlight novel applications of BMPMPA in bioconjugation chemistry and proteolysis-targeting chimeras (PROTACs). These cutting-edge applications respond to frequent queries about "emerging uses of brominated heterocycles" and "next-generation drug discovery tools." The compound's structure-activity relationship continues to be explored through computational modeling and high-throughput screening techniques.

Market analysis reveals steady growth in the pyrazole derivatives segment, with 1006473-56-8 maintaining a niche but important position. Pricing trends correlate with searches for "bromopyrazole cost analysis" and show seasonal variations based on raw material availability. Quality control standards have become increasingly stringent, reflecting the pharmaceutical industry's emphasis on impurity profiling and regulatory compliance.

Environmental considerations for 2-(4-Bromo-3-methyl-1H-pyrazol-1-yl)-2-methylpropanoic acid production align with current industry focus on "green chemistry metrics." Recent process improvements have reduced organic solvent consumption by 30-40% compared to traditional methods, addressing common search concerns about "sustainable chemical manufacturing." These advancements position BMPMPA as a case study in eco-friendly intermediate synthesis.

Future research directions for CAS 1006473-56-8 include exploration of its biological activity spectrum and potential as a molecular scaffold for diverse applications. The compound's versatility ensures its continued relevance in answering search queries like "multifunctional pyrazole derivatives" and "custom heterocyclic building blocks." As synthetic methodologies advance, 2-(4-Bromo-3-methyl-1H-pyrazol-1-yl)-2-methylpropanoic acid will likely play an expanding role in cutting-edge chemical research.

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• 177940-21-5(2-[1-(propan-2-yl)-1H-pyrazol-3-yl]ethan-1-ol)
• 180741-46-2(3-(5-Methyl-1H-pyrazol-1-yl)propanoic acid)
• 942631-65-4(1-(propan-2-yl)-1H-pyrazole-3-carboxylic acid)
• 436086-92-9(3-(3,5-dimethyl-1H-pyrazol-1-yl)-2-methylpropanoic acid)
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• 180741-30-4((3-methyl-1H-pyrazol-1-yl)acetic acid)
• 180741-44-0(2-(5-Methyl-1H-pyrazol-1-yl)acetic acid)
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