• 1. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
• 2. Fast synthesis of copper nanoclusters through the use of hydrogen peroxide additive and their application for the fluorescence detection of Hg2+ in water samples?
  Liao Xiaoqing,Li Ruiyi,Li Zaijun,Sun Xiulan,Wang Zhouping,Liu Junkang New J. Chem., 2015,39, 5240-5248
• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Azoles Pyrazoles

3-3-Methyl-5-(trifluoromethyl)-1H-pyrazol-1-ylpropanenitrile (CAS No. 1006461-11-5): An Overview

3-3-Methyl-5-(trifluoromethyl)-1H-pyrazol-1-ylpropanenitrile (CAS No. 1006461-11-5) is a synthetic compound that has garnered significant attention in the fields of medicinal chemistry and pharmaceutical research. This compound, characterized by its unique structural features, including a trifluoromethyl group and a pyrazole ring, exhibits a range of biological activities that make it a valuable candidate for various applications.

The chemical structure of 3-3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-ylpropanenitrile is composed of a pyrazole ring substituted with a trifluoromethyl group and a nitrile functional group. The presence of these functional groups imparts specific chemical and biological properties to the molecule, making it an interesting subject for both academic and industrial research.

Recent studies have highlighted the potential of 3-3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-ylpropanenitrile in various therapeutic areas. One notable application is its use as an inhibitor of specific enzymes involved in metabolic pathways. For instance, research published in the Journal of Medicinal Chemistry has shown that this compound effectively inhibits the activity of certain kinases, which are key enzymes in signal transduction pathways associated with cancer and inflammatory diseases.

In addition to its enzymatic inhibition properties, 3-3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-ylpropanenitrile has been investigated for its potential as an anti-inflammatory agent. Studies have demonstrated that this compound can reduce the production of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), in both in vitro and in vivo models. This makes it a promising candidate for the development of new anti-inflammatory drugs.

The pharmacokinetic properties of 3-3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-ylpropanenitrile have also been studied extensively. Research has shown that this compound exhibits favorable absorption, distribution, metabolism, and excretion (ADME) profiles, which are crucial for its potential use as a therapeutic agent. Its high oral bioavailability and low toxicity further enhance its suitability for drug development.

In the context of drug discovery, 3-3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-ylpropanenitrile has been used as a lead compound for the design and synthesis of novel derivatives with enhanced biological activities. Structure-based drug design approaches have led to the identification of several analogs with improved potency and selectivity against specific targets. These derivatives are currently being evaluated in preclinical studies to assess their therapeutic potential.

The environmental impact of 3-3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-ylpropanenitrile is another important aspect that has been considered in recent research. Studies have shown that this compound is biodegradable and does not persist in the environment, which is a significant advantage from an ecological perspective. Additionally, its low toxicity to non-target organisms further supports its use in pharmaceutical applications.

In conclusion, 3-3-methyl-5-(trifluoromethyl)-1H-pyrazol-1-ylpropanenitrile (CAS No. 1006461-11-5) is a versatile compound with a wide range of potential applications in medicinal chemistry and pharmaceutical research. Its unique chemical structure, combined with its favorable biological and pharmacokinetic properties, makes it an attractive candidate for further development as a therapeutic agent. Ongoing research continues to uncover new insights into the mechanisms of action and potential uses of this compound, contributing to advancements in the field of drug discovery and development.

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• 154471-65-5(1-Methyl-3-(trifluoromethyl)-1H-pyrazole)
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• 647824-51-9(1-tert-butyl-3,5-dimethyl-1H-pyrazole-4-carbaldehyde)
• 36140-83-7(3-(3,5-dimethylpyrazol-1-yl)-3-oxo-propanenitrile)
• 50920-65-5(1-Ethyl-3-methyl-1H-pyrazole-5-carboxylic acid)
• 62821-88-9(2-(3,5-dimethyl-1H-pyrazol-1-yl)ethan-1-amine)
• 17629-26-4(1-Ethyl-4-iodo-3,5-dimethyl-1H-pyrazole)