• 1. Bismuth(iii) triflate promoted intramolecular hydroamination of unactivated alkenyl sulfonamides in the preparation of pyrrolidines
  Franti?ek Mathia,Peter Szolcsányi Org. Biomol. Chem. 2012 10 2830
• 2. Exploring the divalent effect in fucosidase inhibition with stereoisomeric pyrrolidine dimers
  Audrey Hottin,Daniel W. Wright,Elena Moreno-Clavijo,Antonio J. Moreno-Vargas,Gideon J. Davies,Jean-Bernard Behr Org. Biomol. Chem. 2016 14 4718
• 3. On the understanding of BF3·Et2O-promoted intra- and intermolecular amination and oxygenation of unfunctionalized olefins
  Chun-Hua Yang,Wen-Wen Fan,Gong-Qing Liu,Lili Duan,Lin Li,Yue-Ming Li RSC Adv. 2015 5 61081
• 4. Index pages
  Nat. Prod. Rep. 1986 3 I1
• 5. Index of subjects
  J. Chem. Soc. Abstr. 1910 98 ii1267

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Pyrrolidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines
• Catalysts and Inorganic Chemicals Inorganic Compounds Salt

Comprehensive Guide to 2-Ethylpyrrolidine (CAS No. 1003-28-7): Properties, Applications, and Industry Insights

2-Ethylpyrrolidine (CAS No. 1003-28-7) is a versatile organic compound belonging to the pyrrolidine family, characterized by its five-membered nitrogen-containing ring structure. This compound has garnered significant attention in pharmaceutical, agrochemical, and specialty chemical industries due to its unique chemical properties and broad applicability. With the increasing demand for nitrogen heterocycles and pyrrolidine derivatives, 2-ethylpyrrolidine stands out as a key intermediate in synthetic chemistry.

The molecular formula of 2-ethylpyrrolidine is C₆H₁₃N, and it features an ethyl group substituted at the 2-position of the pyrrolidine ring. This structural modification enhances its reactivity and solubility, making it a valuable building block for drug discovery and material science. Researchers and manufacturers often seek high-purity 2-ethylpyrrolidine for applications ranging from catalysis to flavor and fragrance formulations.

In recent years, the surge in interest for sustainable chemistry and green synthesis has propelled the exploration of 2-ethylpyrrolidine as a potential eco-friendly solvent or reagent. Its low toxicity profile compared to traditional solvents aligns with global trends toward environmentally friendly chemicals. Additionally, the compound's role in bioactive molecule synthesis has been highlighted in peer-reviewed studies, particularly in the development of central nervous system (CNS) therapeutics.

The synthesis of 2-ethylpyrrolidine typically involves hydrogenation of corresponding pyrrole derivatives or reductive amination processes. Advanced purification techniques such as distillation and chromatography ensure the delivery of pharmaceutical-grade 2-ethylpyrrolidine, which is crucial for sensitive applications. Quality control parameters including assay percentage, water content, and residual solvent levels are strictly monitored to meet industry standards.

From a commercial perspective, the global market for pyrrolidine derivatives is projected to grow steadily, driven by demand from the pharmaceutical sector and electronic materials industry. 2-Ethylpyrrolidine suppliers are increasingly focusing on custom synthesis services and bulk manufacturing capabilities to cater to diverse client needs. The compound's stability under various storage conditions and compatibility with common organic solvents further enhances its industrial utility.

Innovative applications of 2-ethylpyrrolidine continue to emerge, particularly in asymmetric synthesis and chiral auxiliary development. Its potential as a ligand in transition metal catalysis has opened new avenues in fine chemical production. Furthermore, the compound's moderate basicity makes it suitable for pH adjustment in specialized formulations, while its volatility profile allows for easy removal after reaction completion.

Safety considerations for handling 2-ethylpyrrolidine emphasize standard organic compound precautions, including proper ventilation and personal protective equipment. While not classified as hazardous under normal conditions, its flammability characteristics and amine odor require appropriate storage in chemical-resistant containers. Material safety data sheets (MSDS) provide comprehensive guidance for workplace handling and emergency procedures.

Analytical characterization of 2-ethylpyrrolidine typically employs gas chromatography (GC), nuclear magnetic resonance (NMR) spectroscopy, and mass spectrometry techniques. These methods ensure accurate identification and quantification, particularly important for GMP-compliant production in regulated industries. Recent advancements in process analytical technology (PAT) have enabled real-time monitoring of 2-ethylpyrrolidine synthesis, improving yield and consistency.

The future outlook for 2-ethylpyrrolidine appears promising, with research focusing on its potential in ionic liquid formulations and energy storage materials. As industries seek alternatives to conventional chemicals, the versatility of this pyrrolidine derivative positions it as a valuable component in next-generation specialty chemical solutions. Continuous innovation in production methodologies and application development will likely expand its market presence in coming years.

• 61772-92-7(Pyrrolidine, 2-butyl-5-heptyl-)
• 736927-54-1(Pyrrolidine, 2-ethyl-5-tridecyl-)
• 61773-00-0(Pyrrolidine, 2-ethyl-5-pentyl-, cis-)
• 61772-96-1(Pyrrolidine, 2-ethyl-5-heptyl-)
• 3446-98-8(2-Butylpyrrolidine)
• 62617-70-3((2R,5R)-2,5-dimethylpyrrolidine)
• 284-18-4(9-Azabicyclo[4.2.1]nonane(7CI,8CI,9CI))
• 61773-01-1(Pyrrolidine, 2-ethyl-5-pentyl-, trans-)
• 767614-75-5(Pyrrolidine,2,5-dipropyl-, (2S,5R)-)
• 86661-34-9(Pyrrolidine, 2-propyl-, (R)-)