• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Excimer and exciplex formation in a pair of bright phosphorescent isomers constructed from Cu3(pyrazolate)3 and Cu3I3 coordination luminophores?
  Shun-Ze Zhan,Mian Li,Xiao-Ping Zhou,Dan Li,Seik Weng Ng RSC Adv., 2011,1, 1457-1459
• 3. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 4. Excellent mechanical performance and enhanced dielectric properties of OBC/SiO2 elastomeric nanocomposites: effect of dispersion of the SiO2 nanoparticles?
  Xing Zhao,Lu Bai,Rui-Ying Bao,Zheng-Ying Liu,Ming-Bo Yang,Wei Yang RSC Adv., 2017,7, 46297-46305
• 5. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita

3-Cyclopropyl-1H-pyrazole: A Comprehensive Overview

The compound with CAS No. 100114-57-6, commonly referred to as 3-Cyclopropyl-1H-pyrazole, is a heterocyclic aromatic compound that has garnered significant attention in the fields of organic chemistry and pharmacology. This molecule belongs to the pyrazole family, which is a five-membered ring containing two nitrogen atoms. The cyclopropyl substituent attached at the 3-position of the pyrazole ring introduces unique electronic and steric properties, making it a valuable compound for various applications.

Pyrazoles are known for their versatility in organic synthesis and their ability to act as building blocks for more complex molecules. The 3-cyclopropyl substitution in this compound adds an additional layer of complexity, enabling it to participate in a wide range of chemical reactions. Recent studies have highlighted its potential as a precursor in the synthesis of bioactive compounds, particularly in the pharmaceutical industry.

One of the most notable applications of 3-Cyclopropyl-1H-pyrazole is its role in drug discovery. Researchers have explored its ability to modulate various biological targets, including enzymes and receptors, which are implicated in diseases such as cancer, inflammation, and neurodegenerative disorders. For instance, a study published in 2023 demonstrated that derivatives of this compound exhibit potent anti-inflammatory activity by inhibiting cyclooxygenase (COX) enzymes.

In addition to its pharmacological applications, 3-Cyclopropyl-1H-pyrazole has also found use in agrochemicals. Its ability to act as a fungicide has been extensively studied, with recent findings indicating that certain analogs can effectively combat plant pathogens without causing harm to crops. This dual functionality underscores the compound's importance in both medicinal and agricultural sciences.

The synthesis of 3-Cyclopropyl-1H-pyrazole involves a series of well-established organic reactions, including cyclization and substitution processes. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly routes to this compound. For example, the use of palladium catalysts has been reported to significantly enhance the yield and purity of the product.

From a structural perspective, the cyclopropyl group attached to the pyrazole ring imparts rigidity and strain, which can influence the molecule's reactivity and selectivity. This property has been exploited in designing novel materials with unique physical and chemical characteristics. For instance, researchers have investigated its potential as a component in advanced polymer systems for electronic applications.

Looking ahead, the continued exploration of 3-Cyclopropyl-1H-pyrazole is expected to yield further insights into its biological and chemical properties. Collaborative efforts between academic institutions and industry players are likely to accelerate its translation into practical applications. As such, this compound remains at the forefront of scientific innovation in organic chemistry.

• 49633-25-2(3-Isopropyl-1H-pyrazole)
• 919123-97-0(3-Butyl-5-propyl-1H-pyrazole)
• 28998-67-6(1H-Pyrazole, 3-butyl-)
• 442886-86-4(1H-Pyrazole,3-ethyl-5-(2-methylpropyl)-)
• 442886-89-7(1H-Pyrazole,3-ethyl-5-(1-methylpropyl)-)
• 442887-08-3(1H-Pyrazole,3-butyl-5-(1-methylethyl)-(9CI))
• 61490-97-9(1H-Pyrazole, 3-butyl-5-pentyl-)
• 14033-09-1(13,14-Diazabicyclo[10.2.1]pentadeca-1(15),12-diene)
• 442886-94-4(1H-Pyrazole,3-(1-methylethyl)-5-propyl-)
• 87585-89-5(1H-Pyrazole, 3-(1,1-dimethylethyl)-5-(1-methylpropyl)-, (S)- (9CI))