• 1. An automatic determination of thoria in thoria-urania mixtures
  Analyst, 1966,91, 208-210
• 2. An intensified π-hole in beryllium-doped boron nitride meshes: its determinant role in CO2 conversion into hydrocarbon fuels?
  Luis Miguel Azofra,Douglas R. MacFarlane,Chenghua Sun Chem. Commun., 2016,52, 3548-3551
• 3. An atomic scale study of defects in Co2FeAl
  Ravi Kumar Yadav,R. Govindaraj Phys. Chem. Chem. Phys., 2020,22, 26876-26886
• 4. An amorphous carbon nitride/NiO/CoN-based composite: a highly efficient nonprecious electrode for supercapacitors and the oxygen evolution reaction?
  Huifang Yang,Haoran Guo,Peidong Fan,Xinpan Li,Wenlu Ren,Rui Song Nanoscale, 2020,12, 7024-7034
• 5. An asymmetric supercapacitor based on controllable WO3 nanorod bundle and alfalfa-derived porous carbon?
  Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Cyclopropanecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Cyclopropanecarboxylic acids and derivatives Cyclopropanecarboxylic acids

2-(((tert-Butoxycarbonyl)amino)methyl)cyclopropanecarboxylic Acid: A Comprehensive Overview

The compound 2-(((tert-Butoxycarbonyl)amino)methyl)cyclopropanecarboxylic acid, identified by the CAS number 1000535-88-5, is a significant molecule in the field of organic chemistry and pharmacology. This compound has garnered attention due to its unique structural features and potential applications in drug discovery and development. The molecule's structure, which includes a cyclopropane ring, a carboxylic acid group, and a tert-butoxycarbonyl (Boc) protected amino group, makes it a versatile building block for various chemical modifications.

Recent studies have highlighted the importance of cyclopropane-containing compounds in medicinal chemistry. The cyclopropane ring in this compound contributes to its rigidity and unique electronic properties, which are crucial for interactions with biological targets. The presence of the Boc group provides an additional layer of functionality, allowing for controlled deprotection during synthesis. This feature is particularly valuable in peptide synthesis and the development of bioactive molecules.

One of the most notable applications of this compound is its role as an intermediate in the synthesis of complex molecules. Researchers have utilized its structure to develop novel antibiotics, antiviral agents, and anticancer drugs. For instance, a study published in Nature Communications demonstrated how this compound can be used as a precursor for designing inhibitors targeting specific enzymes involved in cancer progression.

The synthesis of 2-(((tert-Butoxycarbonyl)amino)methyl)cyclopropanecarboxylic acid involves a multi-step process that combines principles from organic synthesis and catalysis. Key steps include the formation of the cyclopropane ring through [2+1] cycloaddition reactions and the subsequent introduction of the Boc-protected amino group. These steps require precise control over reaction conditions to ensure high yields and purity.

In terms of biological activity, this compound has shown promise in preclinical studies. Its ability to modulate cellular pathways makes it a candidate for further investigation in therapeutic areas such as inflammation, neurodegenerative diseases, and infectious diseases. A recent study published in Journal of Medicinal Chemistry explored its potential as an anti-inflammatory agent, demonstrating significant reduction in cytokine production in vitro.

The integration of computational chemistry techniques has further enhanced our understanding of this compound's properties. Molecular docking studies have revealed potential binding modes with target proteins, providing insights into its mechanism of action. Additionally, quantum chemical calculations have shed light on its electronic structure and reactivity, aiding in the design of more potent derivatives.

In conclusion, 2-(((tert-Butoxycarbonyl)amino)methyl)cyclopropanecarboxylic acid represents a valuable tool in modern organic chemistry and pharmacology. Its unique structure, versatile functional groups, and promising biological activity position it as a key player in the development of innovative therapeutic agents. As research continues to uncover new applications and mechanisms, this compound will undoubtedly remain at the forefront of scientific exploration.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)