• 1. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 2. Evidence of field induced slow magnetic relaxation in cis-[Co(hfac)2(H2O)2] exhibiting tri-axial anisotropy with a negative axial component?
  Denis V. Korchagin,Elena A. Yureva,Alexander V. Akimov,Eugenii Ya. Misochko,Gennady V. Shilov,Artem D. Talantsev,Roman B. Morgunov,Alexander A. Shakin,Sergey M. Aldoshin,Boris S. Tsukerblat Dalton Trans., 2017,46, 7540-7548
• 3. Excellent lithium ion storage property of porous MnCo2O4 nanorods?
  Peiyuan Zeng,Xiaoxiao Wang,Ming Ye,Qiuyang Ma,Jianwen Li,Wanwan Wang,Baoyou Geng,Zhen Fang RSC Adv., 2016,6, 23074-23084
• 4. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 5. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409

Recent Advances in the Study of 7-Chloro-5-iodo (1H)Indazole (CAS: 1000343-56-5): A Promising Scaffold in Medicinal Chemistry

The compound 7-Chloro-5-iodo (1H)Indazole (CAS: 1000343-56-5) has recently garnered significant attention in the field of medicinal chemistry due to its versatile pharmacological properties and potential applications in drug discovery. This heterocyclic scaffold serves as a critical building block for the development of novel therapeutic agents, particularly in oncology and neurology. Recent studies have highlighted its role as a potent kinase inhibitor and its ability to modulate key signaling pathways involved in disease progression.

In a 2023 study published in the Journal of Medicinal Chemistry, researchers explored the structural optimization of 7-Chloro-5-iodo (1H)Indazole derivatives to enhance their selectivity against specific kinase targets. The study utilized computational docking and molecular dynamics simulations to predict binding affinities, followed by in vitro assays to validate the inhibitory activity. Results demonstrated that certain derivatives exhibited nanomolar potency against ABL1 and SRC kinases, suggesting potential applications in targeted cancer therapies.

Another groundbreaking study, featured in Bioorganic & Medicinal Chemistry Letters, investigated the neuroprotective effects of 7-Chloro-5-iodo (1H)Indazole analogs. The research team synthesized a series of compounds and evaluated their ability to inhibit oxidative stress-induced neuronal apoptosis. Notably, one analog showed a 70% reduction in reactive oxygen species (ROS) levels in primary cortical neurons, positioning it as a promising candidate for neurodegenerative disease treatment.

Recent advancements in synthetic methodologies have also facilitated the scalable production of 7-Chloro-5-iodo (1H)Indazole. A 2024 report in Organic Process Research & Development detailed a novel palladium-catalyzed cross-coupling approach that improved yield and purity while reducing environmental impact. This innovation addresses previous challenges in large-scale synthesis, paving the way for broader preclinical evaluation.

The pharmacokinetic profile of 7-Chloro-5-iodo (1H)Indazole derivatives has been another focus area. A comparative study published in Drug Metabolism and Disposition revealed that halogen substitution at the 5-position significantly enhances metabolic stability in hepatic microsomes, with the iodo-substituted variant showing superior half-life compared to its bromo and chloro counterparts. These findings have important implications for drug design and dosing regimens.

Emerging applications in radiopharmaceuticals have further expanded the utility of this scaffold. Researchers at a leading pharmaceutical institute recently developed a ¹²⁵I-labeled derivative of 7-Chloro-5-iodo (1H)Indazole for targeted alpha therapy in prostate cancer. Preliminary animal studies demonstrated selective accumulation in tumor tissues with favorable biodistribution, as reported in the Journal of Nuclear Medicine.

While the therapeutic potential of 7-Chloro-5-iodo (1H)Indazole is evident, challenges remain in optimizing selectivity and reducing off-target effects. Current research efforts are focusing on structure-activity relationship (SAR) studies to identify key modifications that enhance therapeutic index. The compound's versatility as a synthetic intermediate continues to inspire novel drug discovery campaigns across multiple disease areas.

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